Literature DB >> 6232351

Huntington's disease: biochemical prediction by determination of GABA synthesis of cultured fibroblasts.

G Göhlich, W Kuhn, H Höhn, H Przuntek.   

Abstract

GABA synthesis in skin fibroblasts from patients with Huntington's chorea was compared with that in a control group by means of the highly specific 3H-muscimol radioreceptor assay. A significantly increased rate of GABA synthesis was found in the group with Huntington's chorea in an early cell passage. The possible use of this method for early diagnosis of Huntington's chorea is considered.

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Year:  1984        PMID： 6232351     DOI： 10.1007/bf00313653

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  7 in total

1.  GABA synthesis by cultured fibroblasts obtained from persons with Huntington's disease.

Authors:  P N Gray; S L Dana
Journal:  J Neurochem       Date:  1979-11       Impact factor: 5.372

2.  Influences ions, enzymes, and detergents on gamma-aminobutyric acid-receptor binding in synaptic membranes of rat brain.

Authors:  S J Enna; S H Snyder
Journal:  Mol Pharmacol       Date:  1977-05       Impact factor: 4.436

3.  Markers for gene expression in cultured cells from the nervous system.

Authors:  S H Wilson; B K Schrier; J L Farber; E J Thompson; R N Rosenberg; A J Blume; M W Nirenberg
Journal:  J Biol Chem       Date:  1972-05-25       Impact factor: 5.157

4.  Determination of GABA levels by a [3H]muscimol radioreceptor assay.

Authors:  R Bernasconi; H Bittiger; J Heid; P Martin
Journal:  J Neurochem       Date:  1980-03       Impact factor: 5.372

5.  Measurement of gamma-aminobutyric acid in human cerebrospinal fluid: radioreceptor assay using [3H]muscimol.

Authors:  K Baraczka; G Sperk
Journal:  Clin Chim Acta       Date:  1981-01-08       Impact factor: 3.786

6.  Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis.

Authors:  J E Seegmiller; F M Rosenbloom; W N Kelley
Journal:  Science       Date:  1967-03-31       Impact factor: 47.728

7.  Glutamic acid decarboxylase and gamma-aminobutyric acid in Huntington's disease fibroblasts and other cultured cells, determined by a [3H]muscimol radioreceptor assay.

Authors:  E Hamel; I E Goetz; E Roberts
Journal:  J Neurochem       Date:  1981-10       Impact factor: 5.372
  7 in total
  2 in total

1.  Electron spin resonance of erythrocytes in Huntington's disease.

Authors:  H Przuntek; P H Kraus; H Vigenschow; K H Mahr
Journal:  J Neurol       Date:  1984       Impact factor: 4.849

2.  Human Dermal Fibroblast: A Promising Cellular Model to Study Biological Mechanisms of Major Depression and Antidepressant Drug Response.

Authors:  Pierre Mesdom; Romain Colle; Elise Lebigot; Séverine Trabado; Eric Deflesselle; Bruno Fève; Laurent Becquemont; Emmanuelle Corruble; Céline Verstuyft
Journal:  Curr Neuropharmacol       Date:  2020       Impact factor: 7.363
  2 in total

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