Literature DB >> 6231081

Effect of S-adenosyl-L-homocysteine upon sleep in p-chlorophenylalanine pretreated rats.

J Louis-Coindet, N Sarda, H Pacheco, M Jouvet.   

Abstract

S-Adenosyl-L-homocysteine (7 mg/kg), administered to PCPA-pretreated rats, was able to restore normal SWS and PS quantities, as well as circadian rhythms. This effect was at its maximum when SAH was injected 48 h after PCPA (400 mg/kg). These results are discussed in terms of post-synaptic synergetic control by SAH of serotonergic and noradrenergic nerve terminals via the periventricular system and caudal medulla in relation to environmental input.

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Year:  1984        PMID: 6231081     DOI: 10.1016/0006-8993(84)91035-7

Source DB:  PubMed          Journal:  Brain Res        ISSN: 0006-8993            Impact factor:   3.252


  1 in total

1.  The role of 5-hydroxytryptophan (5-HTP) in the regulation of the sleep/wake cycle in parachlorophenylalanine (p-CPA) pretreated rat: a multiple approach study.

Authors:  M Touret; N Sarda; A Gharib; M Geffard; M Jouvet
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

  1 in total

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