| Literature DB >> 6231023 |
Abstract
Incubation of isolated rat islets of Langerhans with [adenine-2,8-3H]NAD+ results in rapid incorporation of 3H into acid-insoluble products. The major site of incorporation appears to be the cell membrane. The reaction is inhibited by nicotinamide, an ADP-ribosylation inhibitor, and stimulated by arginine, an ADP-ribose acceptor. The results demonstrate that islet membrane proteins can be ADP-ribosylated in the absence of exogenous ADP-ribosylating agents and suggest that ADP-ribosylation plays a role in pancreatic islet cell function.Entities:
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Year: 1984 PMID： 6231023 DOI： 10.1016/0006-291x(84)91354-8
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575