Sequence of centromere separation in cultured human amniotic cells.

The sequence of centromere division was analysed in 100 selected late metaphase mitoses of cultured human amniotic cells. The pattern obtained was very similar to that of the previously studied lymphocytes; Chromosomes 18, 12, 17, 5 and X proved to be early dividing, and the acrocentrics were the last to separate in both amniotic cells and blood lymphocytes.