Literature DB >> 6230534

Isolation and characterization of MMS-sensitive mutants of Neurospora crassa.

H Inoue, C Ishii.   

Abstract

Seven different mutants that show high sensitivity to MMS killing were isolated and mapped at different loci. One group, mms-(SA1), mms-(SA2) and mms-(SA6), showed high sensitivity to MMS but not to UV or gamma-rays. Another group, mms-(SA4) and mms-(SA5), showed extremely high sensitivity to UV and MMS. And mms-(SA3) and mms-(SA7) were moderately sensitive to both UV and MMS. Mms-(SA4) and mms-(SA1) were identified as alleles of uvs-2 and mus-7, respectively, which had been previously isolated. The mms-(SA1), mms-(SA6) and mms-(SA7) strains were barren in homozygous crosses, and the mms-(SA5) strain was barren in heterozygous crosses. The mms-(SA1), mms-(SA3) and mms-(SA5) strains showed high sensitivity to histidine. In summary, at least two new loci involved in the repair of MMS damage have been identified. The possibility that some of these new mutants are in new repair pathways is suggested.

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Year:  1984        PMID： 6230534     DOI： 10.1016/0027-5107(84)90068-x

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  12 in total

1.  Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora.

Authors:  Kazuma Ishibashi; Keiichiro Suzuki; Yoshinori Ando; Chihiro Takakura; Hirokazu Inoue
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-26       Impact factor: 11.205

2.  A novel phenotype of an excision-repair mutant in Neurospora crassa: mutagen sensitivity of the mus-18 mutant is specific to UV.

Authors:  C Ishii; K Nakamura; H Inoue
Journal:  Mol Gen Genet       Date:  1991-08

3.  Neurospora mutants sensitive both to mutagens and to histidine.

Authors:  D Newmeyer
Journal:  Curr Genet       Date:  1984-12       Impact factor: 3.886

4.  Histone H1 Is required for proper regulation of pyruvate decarboxylase gene expression in Neurospora crassa.

Authors:  H Diego Folco; Michael Freitag; Ana Ramón; Esteban D Temporini; María E Alvarez; Irene García; Claudio Scazzocchio; Eric U Selker; Alberto L Rosa
Journal:  Eukaryot Cell       Date:  2003-04

5.  Relationship of histidine sensitivity to DNA damage and stress induced responses in mutagen sensitive mutants of Neurospora crassa.

Authors:  C A Howard; T I Baker
Journal:  Curr Genet       Date:  1988-05       Impact factor: 3.886

6.  Growth defect and mutator phenotypes of RecQ-deficient Neurospora crassa mutants separately result from homologous recombination and nonhomologous end joining during repair of DNA double-strand breaks.

Authors:  Akihiro Kato; Hirokazu Inoue
Journal:  Genetics       Date:  2005-10-11       Impact factor: 4.562

7.  The Neurospora crassa mus-19 gene is identical to the qde-3 gene, which encodes a RecQ homologue and is involved in recombination repair and postreplication repair.

Authors:  Akihiro Kato; Yufuko Akamatsu; Yoshiyuki Sakuraba; Hirokazu Inoue
Journal:  Curr Genet       Date:  2003-11-01       Impact factor: 3.886

8.  Highly efficient gene replacements in Neurospora strains deficient for nonhomologous end-joining.

Authors:  Yuuko Ninomiya; Keiichiro Suzuki; Chizu Ishii; Hirokazu Inoue
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-06       Impact factor: 11.205

9.  The Neurospora uvs-2 gene encodes a protein which has homology to yeast RAD18, with unique zinc finger motifs.

Authors:  H Tomita; T Soshi; H Inoue
Journal:  Mol Gen Genet       Date:  1993-04

10.  Neurosprora crassa RAD5 homologue, mus-41, inactivation results in higher sensitivity to mutagens but has little effect on PCNA-ubiquitylation in response to UV-irradiation.

Authors:  Tsuyoshi Kawabata; Akihiro Kato; Keiichiro Suzuki; Hirokazu Inoue
Journal:  Curr Genet       Date:  2007-08-17       Impact factor: 3.886
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