Literature DB >> 6230252

Reversible impairment of hepatobiliary function induced by streptozotocin in the rat.

C E Carnovale, E A Rodriguez Garay.   

Abstract

The effect of streptozotocin (SZ) on hepatobiliary function was studied in rats on the 1st, 7th and 15th days of treatment. Serum glucose increased significantly on the 1st day, and then remained high. Bile flow, bile acids output and BSP biliary excretion were significantly decreased on the 1st day of treatment, whereas serum sorbitol dehydrogenase was increased. All the parameters tested apart from serum glucose tended to normalize with time. The results suggested a transient toxic effect of SZ on the hepatocyte.

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Year:  1984        PMID： 6230252     DOI： 10.1007/bf01947564

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  17 in total

1.  The application of thin layer chromatography to sulfobromophthalein metabolism studies.

Authors:  F J WHELAN; G L PLAA
Journal:  Toxicol Appl Pharmacol       Date:  1963-07       Impact factor: 4.219

2.  [Pathological occurrence of sorbitol dehydrogenase in blood in liver diseases].

Authors:  U GERLACH
Journal:  Klin Wochenschr       Date:  1957-11-15

Review 3.  Mechanisms and control of secretion of bile water and electrolytes.

Authors:  S Erlinger; D Dhumeaux
Journal:  Gastroenterology       Date:  1974-02       Impact factor: 22.682

4.  Effects of streptozotocin on carbohydrate and lipid metabolism in the rat.

Authors:  P S Schein; K G Alberti; D H Williamson
Journal:  Endocrinology       Date:  1971-09       Impact factor: 4.736

5.  Biliary flow after microsomal enzyme induction.

Authors:  C D Klaassen
Journal:  J Pharmacol Exp Ther       Date:  1969-08       Impact factor: 4.030

6.  Studies of the diabetogenic action of streptozotocin.

Authors:  A Junod; A E Lambert; L Orci; R Pictet; A E Gonet; A E Renold
Journal:  Proc Soc Exp Biol Med       Date:  1967-10

7.  Mechanism of phenobarbital-induced hypercholeresis in the rat.

Authors:  P Berthelot; S Erlinger; D Dhumeaux; A M Preaux
Journal:  Am J Physiol       Date:  1970-09

8.  Maximum biliary excretion of bilirubin and sulfobromophthalein during anesthesia-induced alteration of rectal temperature.

Authors:  R J Roberts; C D Klaassen; G L Plaa
Journal:  Proc Soc Exp Biol Med       Date:  1967-05

9.  Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin.

Authors:  R N Arison; E I Ciaccio; M S Glitzer; J A Cassaro; M P Pruss
Journal:  Diabetes       Date:  1967-01       Impact factor: 9.461

10.  Acute aflatoxicosis in guinea pigs: sequential changes in serum proteins, complement, C4, and liver enzymes and histopathologic changes.

Authors:  J R Thurston; A L Baetz; N F Cheville; J L Richard
Journal:  Am J Vet Res       Date:  1980-08       Impact factor: 1.156
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  1 in total

1.  Diethylnitrosamine Increases Proliferation in Early Stages of Hepatic Carcinogenesis in Insulin-Treated Type 1 Diabetic Mice.

Authors:  A S Arboatti; F Lambertucci; M G Sedlmeier; G Pisani; J Monti; M de L Álvarez; D E A Francés; M T Ronco; C E Carnovale
Journal:  Biomed Res Int       Date:  2018-04-23       Impact factor: 3.411
  1 in total

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