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Literature DB >> 6229805

Decreased morphine intake by opiate addicted rats administered zimelidine, a 5-HT uptake inhibitor.

L Rönnbäck, J Zeuchner, L Rosengren, A Wronski, S O Ogren.

Abstract

Zimelidine, a specific 5-HT uptake inhibitor, reduced peroral morphine consumption by morphine-addicted adult male and female Sprague-Dawley rats and old male rats in choice tests. The effect was dose dependent in male rats. Thus, the availability of central 5-HT appears to be important for the regulation of morphine preference in rat. The results are discussed in relation to recent literature where ethanol preference has been found to be attenuated by zimelidine. The results may provide insights into the complex cellular mechanisms underlying opiate addiction.

Entities: Chemical Species

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Year: 1984 PMID： 6229805 DOI： 10.1007/bf00426376

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

24 in total

Review 1. Molecular actions of opiates: historical overview and new findings on opiate receptor interactions with enkephalins and guanyl nucleotides.

Authors: S H Snyder; S R Childers; I Creese
Journal: Adv Biochem Psychopharmacol Date: 1979

2. (Z)-dimethylamino-1-(4-bromophenyl)-1-(3-pyridyl) propene (h 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake.

Authors: S B Ross; S O Ogren; A L Renyi
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1976-08

3. Physical dependence on morphine fails to increase serotonin turnover rate in rat brain.

Authors: S Algeri; E Costa
Journal: Biochem Pharmacol Date: 1971-04 Impact factor: 5.858

4. A rat model of alcoholism?

Authors: D Lester; E X Freed
Journal: Ann N Y Acad Sci Date: 1972-05-25 Impact factor: 5.691

5. Brain serotonin turnover in morphine tolerant and dependent mice.

Authors: F H Shen; H H Loh; E L Way
Journal: J Pharmacol Exp Ther Date: 1970-11 Impact factor: 4.030

6. Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues.

Authors: S B Ross; A L Renyi
Journal: Neuropharmacology Date: 1977-01 Impact factor: 5.250

Decreased morphine intake by opiate addicted rats administered zimelidine, a 5-HT uptake inhibitor.

Review 1. Molecular actions of opiates: historical overview and new findings on opiate receptor interactions with enkephalins and guanyl nucleotides.

2. (Z)-dimethylamino-1-(4-bromophenyl)-1-(3-pyridyl) propene (h 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake.

3. Physical dependence on morphine fails to increase serotonin turnover rate in rat brain.

4. A rat model of alcoholism?

5. Brain serotonin turnover in morphine tolerant and dependent mice.

6. Inhibition of the neuronal uptake of 5-hydroxytryptamine and noradrenaline in rat brain by (Z)- and (E)-3-(4-bromophenyl)-N,N-dimethyl-3-(3-pyridyl) allylamines and their secondary analogues.

7. Morphine tolerance, physical dependence, and synthesis of brain 5-hydroxytryptamine.

8. The effect of 6-hydroxydopamine on the antinociceptive action of morphine.

9. The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor.

10. A new ingestion method for long-term morphine intoxication in rat.

1. Morphine preference in individual rats after morphine ingestion.

2. Neurotransmitter uptake in various brain regions of chronically morphinized rats.