Literature DB >> 6229714

Knowledge-based simulation of genetic regulation in bacteriophage lambda.

S Meyers, P Friedland.   

Abstract

We have developed a general-purpose computer program for the functional simulation of regulatory genetics. This simulator is knowledge-based and was developed using the Unit System, a software tool for the acquisition, representation, and manipulation of hierarchically organized knowledge. The advantages of a knowledge-based design are presented, and the simulator's architecture is described. Its performance on the decision between lytic and lysogenic growth in Bacteriophage Lambda is reported.

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Year:  1984        PMID： 6229714      PMCID： PMC320979          DOI： 10.1093/nar/12.1part1.1

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  3 in total

1.  A complex control circuit. Regulation of immunity in temperate bacteriophages.

Authors:  R Thomas; A M Gathoye; L Lambert
Journal:  Eur J Biochem       Date:  1976-12

2.  Internist-1, an experimental computer-based diagnostic consultant for general internal medicine.

Authors:  R A Miller; H E Pople; J D Myers
Journal:  N Engl J Med       Date:  1982-08-19       Impact factor: 91.245

3.  Discovery, confirmation, and incorporation of causal relationships from a large time-oriented clinical data base: the RX project.

Authors:  R L Blum
Journal:  Comput Biomed Res       Date:  1982-04
  3 in total
  2 in total

1.  Frameshift suppressor mutations outside the anticodon in yeast proline tRNAs containing an intervening sequence.

Authors:  C M Cummins; M R Culbertson; G Knapp
Journal:  Mol Cell Biol       Date:  1985-07       Impact factor: 4.272

2.  Structure of the sucrose synthase gene on chromosome 9 of Zea mays L.

Authors:  W Werr; W B Frommer; C Maas; P Starlinger
Journal:  EMBO J       Date:  1985-06       Impact factor: 11.598
  2 in total

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