Literature DB >> 6228662

Huntington's disease in monozygotic twins reared apart.

L Sudarsky, R H Myers, T M Walshe.   

Abstract

Monozygotic twins, identical by serological studies, with Huntington's disease are described who were raised in separate households from birth. Age at onset, landmarks of the disease, and behavioural abnormalities were strikingly similar. Previously reported twin studies in Huntington's disease are reviewed. Twin data support the hypothesis that age at onset and several other clinical features of the illness are substantially determined by genetic mechanisms.

Entities:  

Mesh：

Year:  1983        PMID： 6228662      PMCID： PMC1049168          DOI： 10.1136/jmg.20.6.408

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  10 in total

1.  Monozygotic twins concordant for Huntington's chorea.

Authors:  N C MYRIANTHOPOULOS; P T ROWLEY
Journal:  Neurology       Date:  1960-05       Impact factor: 9.910

2.  Monozygotic twins with concordant Huntington's chorea and discordant hemiplegia.

Authors:  H C JELGERSMA
Journal:  Folia Psychiatr Neurol Neurochir Neerl       Date:  1957-02

3.  Paraplegia in flexion of cerebral origin.

Authors:  P I YAKOVLEV
Journal:  J Neuropathol Exp Neurol       Date:  1954-01       Impact factor: 3.685

4.  A family study of Huntington's chorea with unusual manifestations.

Authors:  G A Perrine; R M Goodman
Journal:  Ann Intern Med       Date:  1966-03       Impact factor: 25.391

5.  Huntington's chorea in the West of Scotland.

Authors:  J M Bolt
Journal:  Br J Psychiatry       Date:  1970-03       Impact factor: 9.319

6.  Huntington disease: functional capacities in patients treated with neuroleptic and antidepressant drugs.

Authors:  I Shoulson
Journal:  Neurology       Date:  1981-10       Impact factor: 9.910

7.  Uptake and efflux of 14-C-dopamine in platelets: evidence for a generalized defect in Parkinson's disease.

Authors:  A Barbeau; G Campanella; R F Butterworth; K Yamada
Journal:  Neurology       Date:  1975-01       Impact factor: 9.910

8.  Chorea Huntington and epilepsy in monozygotic twins.

Authors:  E Schiottz-Christensen
Journal:  Eur Neurol       Date:  1969       Impact factor: 1.710

9.  Factors related to onset age of Huntington disease.

Authors:  R H Myers; J J Madden; J L Teague; A Falek
Journal:  Am J Hum Genet       Date:  1982-05       Impact factor: 11.025

10.  Long-term treatment of juvenile Huntington's chorea with dipropylacetic acid.

Authors:  D S Bachman; I J Butler; G M McKhann
Journal:  Neurology       Date:  1977-02       Impact factor: 9.910
  10 in total
  2 in total

1.  Maternal factors in onset of Huntington disease.

Authors:  R H Myers; L A Cupples; M Schoenfeld; R B D'Agostino; N C Terrin; N Goldmakher; P A Wolf
Journal:  Am J Hum Genet       Date:  1985-05       Impact factor: 11.025

2.  Late onset of Huntington's disease.

Authors:  R H Myers; D S Sax; M Schoenfeld; E D Bird; P A Wolf; J P Vonsattel; R F White; J B Martin
Journal:  J Neurol Neurosurg Psychiatry       Date:  1985-06       Impact factor: 10.154
  2 in total

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