Literature DB >> 6228566

A luteinizing hormone-releasing hormone agonist decreases biological activity and modifies chromatographic behavior of luteinizing hormone in man.

R M Evans, G C Doelle, J Lindner, V Bradley, D Rabin.   

Abstract

The effect of the luteinizing hormone-releasing hormone (LHRH) agonist, [D-Trp6,Pro9-NEth]LHRH (LHRHA), on luteinizing hormone (LH) bioactivity was assessed with a rat interstitial cell assay in four men during a 14-d treatment period. Biologic/immunologic (B/I) ratios were unchanged initially with treatment but by day 12 had fallen to levels lower than basal values. Frequent sampling on day 12 revealed blunted gonadotropin responsiveness to LHRHA and absence of spontaneous LH pulsations. Despite continued administration of LHRHA, human chorionic gonadotropin administration resulted in elevated B/I ratios and testosterone levels. Further characterization of the serum immunoreactive LH by Sephadex chromatography revealed a later elution profile during treatment with LHRHA. Thus, LHRHA appears to act, in part, by modification of the bioactivity of LH in man.

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Year:  1984        PMID： 6228566      PMCID： PMC425009          DOI： 10.1172/JCI111200

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  13 in total

1.  Heterogeneity of purified human pituitary luteinizing hormone: effect on hormone measurement by radioimmunoassay.

Authors:  R Benveniste; L A Frohman; D Rabinowitz
Journal:  Endocrinology       Date:  1975-07       Impact factor: 4.736

2.  A highly sensitive in vitro bioassay for luteinizing hormone and chorionic gonadotropin: testosterone production by dispersed Leydig cells.

Authors:  M L Dufau; C R Mendelson; K J Catt
Journal:  J Clin Endocrinol Metab       Date:  1974-09       Impact factor: 5.958

3.  Gonadal function and the biological and physicochemical properties of follicle stimulating hormone.

Authors:  W D Peckham; T Yamaji; D J Dierschke; E Knobil
Journal:  Endocrinology       Date:  1973-06       Impact factor: 4.736

4.  Retention of in vitro biological activities by desialylated human luteinizing hormone and chorionic gonadotropin.

Authors:  M L Dufau; K J Catt; T Tsuruhara
Journal:  Biochem Biophys Res Commun       Date:  1971-09       Impact factor: 3.575

5.  The effects of ovariectomy, estrogen replacement, and neuraminidase treatment on the properties of the adenohypophysial glycoprotein hormones of the Rhesus monkey.

Authors:  W D Peckham; E Knobil
Journal:  Endocrinology       Date:  1976-04       Impact factor: 4.736

6.  Contribution of subunits to the function of luteinizing hormone/human chorionic gonadotropin recombinants.

Authors:  T W Strickland; D Puett
Journal:  Endocrinology       Date:  1981-12       Impact factor: 4.736

7.  Hypogonadism in a male with an immunologically active, biologically inactive luteinizing hormone: characterization of the abnormal hormone.

Authors:  I Z Beitins; L Axelrod; T Ostrea; R Little; T M Badger
Journal:  J Clin Endocrinol Metab       Date:  1981-06       Impact factor: 5.958

8.  Comparison of in-vitro bioactivity and immunoreactivity of serum LH in normal cyclic and hypogonadal women treated with low doses of LH-RH.

Authors:  J E Sawyer-Steffan; B L Lasley; J D Hoff; S S Yen
Journal:  J Reprod Fertil       Date:  1982-05

9.  Effects of luteinizing hormone releasing hormone (LHRH) upon bioactive and immunoreactive serum LH levels in normal subjects.

Authors:  M L Dufau; I Z Beitins; J W McArthur; K J Catt
Journal:  J Clin Endocrinol Metab       Date:  1976-09       Impact factor: 5.958

10.  In vitro bioassay of LH in human serum: the rat interstitial cell testosterone (RICT) assay.

Authors:  M L Dufau; R Pock; A Neubauer; K J Catt
Journal:  J Clin Endocrinol Metab       Date:  1976-05       Impact factor: 5.958
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  7 in total

1.  Luteinizing hormone determinations obtained with either a monoclonal and a polyclonal antibody radioimmunoassay and their correlations with clinical findings.

Authors:  P L Venturini; V Remorgida; V Aguggia; L De Cecco
Journal:  J Endocrinol Invest       Date:  1990-03       Impact factor: 4.256

2.  Radioimmunoassay for 6-D-tryptophan analog of luteinizing hormone-releasing hormone: measurement of serum levels after administration of long-acting microcapsule formulations.

Authors:  M Mason-Garcia; S Vigh; A M Comaru-Schally; T W Redding; A Somogyvari-Vigh; J Horvath; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

3.  Dissociated effect of buserelin on luteinizing hormone (LH) and alpha subunit in men.

Authors:  G Valenti; L Denti; A Banchini; G Ceresini; G P Ceda; W C Westel; A Negro-Vilar
Journal:  J Endocrinol Invest       Date:  1990-06       Impact factor: 4.256

Review 4.  Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions.

Authors:  P Chrisp; K L Goa
Journal:  Drugs       Date:  1990-04       Impact factor: 9.546

5.  Inhibition of growth of a prolactin and growth hormone-secreting pituitary tumor in rats by D-tryptophan-6 analog of luteinizing hormone-releasing hormone.

Authors:  I Torres-Aleman; T W Redding; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

6.  Inhibition of gonadotropic and ovarian function by intranasal administration of D-Ser (TBU)6-EA10-LHRH in normo-ovulatory women and patients with polycystic ovary disease.

Authors:  J Smitz; P Devroey; M Camus; J Deschacht; L Van Waesberghe; A Wisanto; A C Van Steirteghem
Journal:  J Endocrinol Invest       Date:  1988-10       Impact factor: 4.256

7.  Effect of dextran on the release of gonadotropin-releasing hormone (GnRH) injected into rats: plasma GnRH and gonadotropin response.

Authors:  N Heinrich; D Lorenz; H Berger; K Fechner; H E Schmidt; H Schäfer; B Mehlis
Journal:  Pharm Res       Date:  1985-09       Impact factor: 4.200
  7 in total

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