Literature DB >> 6227285

Inhibition by secalonic acid D of oxidative phosphorylation and Ca2+-induced swelling in mitochondria isolated from rat livers.

K Kawai, T Nakamaru, Y Maebayashi, Y Nozawa, M Yamazaki.   

Abstract

The in vitro biological activity of secalonic acid D, a mycotoxin from Aspergillus ochraceus, was studied to assess its cytotoxicity for isolated rat liver mitochondria. Secalonic acid D uncoupled the oxidative phosphorylation of mitochondria and caused a mild inhibition of state 3 respiration. Secalonic acid D weakly enhanced latent ATPase activity in mitochondria but suppressed 2,4-dinitrophenol-stimulated ATPase activity. Secalonic acid D did not induce pseudoenergized swelling of mitochondria and markedly inhibited the Ca2+-induced swelling of mitochondria in KCl isotonic solution.

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Year:  1983        PMID： 6227285      PMCID： PMC239469          DOI： 10.1128/aem.46.4.793-796.1983

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  16 in total

1.  The osmotic behavior and permeability to non-electrolytes of mitochondria.

Authors:  H TEDESCHI; D L HARRIS
Journal:  Arch Biochem Biophys       Date:  1955-09       Impact factor: 4.013

2.  The inhibitory effect of uncouplers of oxidative phosphorylation on mitochondrial respiration.

Authors:  K Van Dam
Journal:  Biochim Biophys Acta       Date:  1967-03-08

3.  Mechanism of inhibition by uncouples of succinate oxidation in isolated mitochondria.

Authors:  S Papa; N E Lofrumento; G Paradies; E Quagliariello
Journal:  Biochim Biophys Acta       Date:  1969-05

4.  The isolation, structure and absolute configuration of secalonic acid D, the toxic metabolite of Penicillium oxalicum.

Authors:  P S Steyn
Journal:  Tetrahedron       Date:  1970-01       Impact factor: 2.457

5.  The isolation of secalonic acid A from Aspergillus ochraceus cultured on rice.

Authors:  M Yamazaki; Y Maebayashi; K Miyaki
Journal:  Chem Pharm Bull (Tokyo)       Date:  1971-01       Impact factor: 1.645

6.  The mechanism of mitochondrial swelling. II. Pseudoenergized swelling in the presence of alkali metal salts.

Authors:  G A Blondin; W J Vail; D E Green
Journal:  Arch Biochem Biophys       Date:  1969-01       Impact factor: 4.013

Review 7.  Transport of protons across membranes by weak acids.

Authors:  S G McLaughlin; J P Dilger
Journal:  Physiol Rev       Date:  1980-07       Impact factor: 37.312

Review 8.  The interaction of highly active uncouplers with mitochondria.

Authors:  H Terada
Journal:  Biochim Biophys Acta       Date:  1981-12-30

9.  Teratogenicity of secalonic acid D in mice.

Authors:  C S Reddy; R V Reddy; A W Hayes; A Ciegler
Journal:  J Toxicol Environ Health       Date:  1981 Mar-Apr

10.  Toxicity of Secalonic acid D.

Authors:  C S Reddy; A W Hayes; W L Williams; A Ciegler
Journal:  J Toxicol Environ Health       Date:  1979-11
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  4 in total

1.  Reexamination of respiration-impairing effect of bikaverin on isolated mitochondria.

Authors:  T Suzuki; A Kitagawa; K Kawai; T Hamasaki
Journal:  Mycotoxin Res       Date:  1998-03       Impact factor: 3.833

2.  Toxicity of emestrin, a new macrocyclic dithiodioxopiperazine mycotoxin, to mitochondrial function.

Authors:  K Kawai; K Ishizaki; T Nakamaru; K Hisada; Y Nozawa
Journal:  Mycotoxin Res       Date:  1989-03       Impact factor: 3.833

3.  Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria.

Authors:  K Kawai; T Nakamaru; Y Nozawa; Y Maebayashi; M Yamazaki; S Natori
Journal:  Appl Environ Microbiol       Date:  1984-11       Impact factor: 4.792

4.  Ergochromes: Heretofore Neglected Side of Ergot Toxicity.

Authors:  Miroslav Flieger; Eva Stodůlková; Stephen A Wyka; Jan Černý; Valéria Grobárová; Kamila Píchová; Petr Novák; Petr Man; Marek Kuzma; Ladislav Cvak; Kirk D Broders; Miroslav Kolařík
Journal:  Toxins (Basel)       Date:  2019-07-25       Impact factor: 4.546
  4 in total

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