Literature DB >> 622575

Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine.

I J Chopra.   

Abstract

Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.

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Year:  1978        PMID： 622575     DOI： 10.1126/science.622575

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

1.  Observations on the factors that control the generation of triiodothyronine from thyroxine in rat liver and the nature of the defect induced by fasting.

Authors:  A Balsam; S H Ingbar
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

2.  Structural requirements of thiol compounds in the inhibition of human liver iodothyronine 5'-deiodinase.

Authors:  R Harbottle; S J Richardson
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

3.  Relationships between iodothyronine peripheral metabolism and ketone bodies during hypocaloric dietary manipulations.

Authors:  R Pasquali; G Baraldi; P Biso; F Pasqui; L Mattioli; M Capelli; R Callivá; M Spoto; N Melchionda; G Labò
Journal:  J Endocrinol Invest       Date:  1983-04       Impact factor: 4.256

4.  The effect of bile salts on thyroxine 5'-monodeiodination in rat liver homogenate.

Authors:  T Mitsuma; M Ukai
Journal:  Experientia       Date:  1981-06

5.  Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from Mus musculus.

Authors:  Jennifer M Buss; Patrick M McTamney; Steven E Rokita
Journal:  Protein Sci       Date:  2012-03       Impact factor: 6.725

6.  L-triiodothyronine and L-reverse-triiodothyronine generation in the human polymorphonuclear leukocyte.

Authors:  K A Woeber
Journal:  J Clin Invest       Date:  1978-09       Impact factor: 14.808

7.  Inhibition of rat hepatic thyroxine 5'-monodeiodinase by propylthiouracil: relation to site of interaction of thyroxine and glutathione.

Authors:  T Yamada; I J Chopra; N Kaplowitz
Journal:  J Endocrinol Invest       Date:  1981 Oct-Dec       Impact factor: 4.256

8.  Formation of diiodotyrosine from thyroxine. Ether-link cleavage, an alternate pathway of thyroxine metabolism.

Authors:  A Balsam; F Sexton; M Borges; S H Ingbar
Journal:  J Clin Invest       Date:  1983-10       Impact factor: 14.808

9.  The role of sulfhydryl groups on the impaired hepatic 3',3,5-triiodothyronine generation from thyroxine in the hypothyroid, starved, fetal, and neonatal rodent.

Authors:  A R Harris; S L Fang; L Hinerfeld; L E Braverman; A G Vagenakis
Journal:  J Clin Invest       Date:  1979-03       Impact factor: 14.808

10.  Properties of cytosolic components activating rat hepatic 5' [corrected]-deiodination in the presence of NADPH.

Authors:  K Sawada; B C Hummel; P G Walfish
Journal:  Biochem J       Date:  1986-03-01       Impact factor: 3.857
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