Literature DB >> 622570

Amantadine: neuromuscular blockade by suppression of ionic conductance of the acetylcholine receptor.

E X Albuquerque, A T Eldefrawi, M E Eldefrawi, N A Mansour, M C Tsai.   

Abstract

Amantadine hydrochloride decreases the sensitivity of denervated mammalian muscle to iontophoretically applied acetylcholine. The drug depresses the amplitude of the end-plate current and reverses the slope of the relation between half-decay time and membrane potential suggesting that it alters the ionic conductance that is mediated by the acetylcholine receptor. Binding studies confirm that amantadine acts on the ion conductance modulator rather than the acetylcholine receptor.

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Year:  1978        PMID： 622570     DOI： 10.1126/science.622570

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Endplate channel actions of a hemicholinium-3 analog, DMAE.

Authors:  K A Alkadhi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-03       Impact factor: 3.000

2.  Forskolin blocks carbachol-mediated ion-permeability of chick myotube nicotinic receptors and inhibits binding of 3H-phencyclidine to Torpedo microsac nicotinic receptors.

Authors:  J Häggblad; H Eriksson; B Hedlund; E Heilbronn
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-10       Impact factor: 3.000

3.  The actions of tubocurarine at the frog neuromuscular junction.

Authors:  D Colquhoun; F Dreyer; R E Sheridan
Journal:  J Physiol       Date:  1979-08       Impact factor: 5.182

4.  Nickel and calcium ions modify the characteristics of the acetylcholine receptor-channel complex at the frog neuromuscular junction.

Authors:  K L Magleby; M M Weinstock
Journal:  J Physiol       Date:  1980-02       Impact factor: 5.182

5.  Tetraethylammonium: voltage-dependent action on endplate conductance and inhibition of ligand binding to postsynaptic proteins.

Authors:  M Adler; A C Oliveira; M E Eldefrawi; A T Eldefrawi; E X Albuquerque
Journal:  Proc Natl Acad Sci U S A       Date:  1979-01       Impact factor: 11.205

6.  Triphenylmethylphosphonium is an ion channel ligand of the nicotinic acetylcholine receptor.

Authors:  L Lauffer; F Hucho
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

7.  [3H]Phencyclidine: a probe for the ionic channel of the nicotinic receptor.

Authors:  M E Eldefrawi; A T Eldefrawi; R S Aronstam; M A Maleque; J E Warnick; E X Albuquerque
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

8.  The effect of (+)-tubocurarine on neuromuscular transmission during repetitive stimulation in the rat, mouse, and frog.

Authors:  K L Magleby; B S Pallotta; D A Terrar
Journal:  J Physiol       Date:  1981-03       Impact factor: 5.182

9.  Current-dependent block of endplate channels by guanidine derivatives.

Authors:  S M Vogel; S Watanabe; J Z Yeh; J M Farley; T Narahashi
Journal:  J Gen Physiol       Date:  1984-06       Impact factor: 4.086
  9 in total

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