Literature DB >> 6225450

Electron microscopic study on the cardiac hypertrophy induced by iron deficiency anaemia in the rat.

M A Rossi, S V Carillo.   

Abstract

In this investigation the ultrastructure of the hypertrophied myocardium of anaemic iron-deficient rats was studied. Iron deficiency anaemia was induced by feeding rats on an iron-deficient diet for 30 days from the time of weaning. Anaemia was indicated by lowering of blood haemoglobin levels. The results clearly demonstrated that experimentally-induced iron deficiency anaemia brings about striking morphological changes in the heart of the rat. These changes were characterized by marked cellular hypertrophy together with distinct cellular degeneration and interstitial fibrosis. It is noteworthy that ultrastructural features of myocardial hypertrophy and degeneration occurred simultaneously. The potential role of noradrenaline in the pathogenesis of these changes is discussed.

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Mesh：

Year:  1983        PMID： 6225450      PMCID： PMC2040798     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN： 0007-1021


  24 in total

1.  Ultrastructural changes in the canine myocardium with right ventricular hypertrophy and congestive heart failure.

Authors:  S P Bishop; C R Cole
Journal:  Lab Invest       Date:  1969-03       Impact factor: 5.662

2.  Regression of left ventricular dilation and hypertrophy after removal of volume overload. Morphological and ultrastructural study.

Authors:  J M Papadimitriou; B E Hopkins; R R Taylor
Journal:  Circ Res       Date:  1974-07       Impact factor: 17.367

3.  Significance of the multiple intercalated disc in the hypertrophied canine heart.

Authors:  G E Adomian; M M Laks; F Morady; H J Swan
Journal:  J Mol Cell Cardiol       Date:  1974-04       Impact factor: 5.000

4.  Myocardial hypertrophy produced by chronic infusion of subhypertensive doses of norepinephrine in the dog.

Authors:  M M Laks; F Morady; H J Swan
Journal:  Chest       Date:  1973-07       Impact factor: 9.410

5.  The myocardium in hyperfunction, hypertrophy and heart failure.

Authors:  F Z Meerson
Journal:  Circ Res       Date:  1969-07       Impact factor: 17.367

6.  Effect of sympathomimetic drugs on protein synthesis in rat heart.

Authors:  S Mallov
Journal:  J Pharmacol Exp Ther       Date:  1973-12       Impact factor: 4.030

7.  Sarcomerogenesis in human myocardium.

Authors:  M J Legato
Journal:  J Mol Cell Cardiol       Date:  1970-12       Impact factor: 5.000

8.  Hypertrophic obstructive cardiomyopathy, a histological, histochemical, and ultrastructural study of biopsy material.

Authors:  S Van Noorden; E G Olsen; A G Pearse
Journal:  Cardiovasc Res       Date:  1971-01       Impact factor: 10.787

9.  Cardiovascular effects of sustained norepinephrine infusions. II. Morphology.

Authors:  E A Schenk; A J Moss
Journal:  Circ Res       Date:  1966-05       Impact factor: 17.367

10.  The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly.

Authors:  D Bartosová; M Chvapil; B Korecký; O Poupa; K Rakusan; Z Turek; M Vízek
Journal:  J Physiol       Date:  1969-02       Impact factor: 5.182
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  5 in total

Review 1.  Anemia, chronic renal disease and congestive heart failure--the cardio renal anemia syndrome: the need for cooperation between cardiologists and nephrologists.

Authors:  Donald S Silverberg; Dov Wexler; Adrian Iaina; Shoshana Steinbruch; Y Wollman; Doron Schwartz
Journal:  Int Urol Nephrol       Date:  2006       Impact factor: 2.370

2.  Sickle cell anemia mice develop a unique cardiomyopathy with restrictive physiology.

Authors:  Nihal Bakeer; Jeanne James; Swarnava Roy; Janaka Wansapura; Shiva Kumar Shanmukhappa; John N Lorenz; Hanna Osinska; Kurt Backer; Anne-Cecile Huby; Archana Shrestha; Omar Niss; Robert Fleck; Charles T Quinn; Michael D Taylor; Enkhsaikhan Purevjav; Bruce J Aronow; Jeffrey A Towbin; Punam Malik
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-08       Impact factor: 11.205

3.  Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy.

Authors:  Lexa Rae Turner; Daniel Aaron Premo; Brett Jason Gibbs; Megan Lesley Hearthway; Madelyne Motsko; Andrea Sappington; LeeAnn Walker; Michael Eugene Mullendore; Herbert George Chew
Journal:  BMC Physiol       Date:  2002-01-09

Review 4.  Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives.

Authors:  Ewa A Jankowska; Stephan von Haehling; Stefan D Anker; Iain C Macdougall; Piotr Ponikowski
Journal:  Eur Heart J       Date:  2012-10-25       Impact factor: 29.983

5.  Disruption of calcium homeostasis in cardiomyocytes underlies cardiac structural and functional changes in severe sepsis.

Authors:  Mara R N Celes; Lygia M Malvestio; Sylvia O Suadicani; Cibele M Prado; Maria J Figueiredo; Erica C Campos; Ana C S Freitas; David C Spray; Herbert B Tanowitz; João S da Silva; Marcos A Rossi
Journal:  PLoS One       Date:  2013-07-23       Impact factor: 3.240
  5 in total

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