Literature DB >> 6225137

Effects of acute doses of zimelidine on REM sleep in rats.

R B Reyes, S Y Hill, D J Kupfer.   

Abstract

Sleep EEG (7 h) were obtained from 11 rats given 5, 10, and 20 mg/kg zimelidine, and a control dose of saline. Zimelidine significantly suppressed REM sleep, lengthened REM latency, and reduced total sleep time (TST) in a dose-dependent manner. Sleep latency was not affected except at the highest dose of zimelidine. Slow-wave sleep (SWS) was not affected at any dose. The results are discussed in terms of their implication for the use of zimelidine in the clinical treatment of depression.

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Year:  1983        PMID： 6225137     DOI： 10.1007/bf00436155

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  18 in total

1.  EEG sleep and tricyclic plasma levels in primary depression.

Authors:  D J Kupfer; I Hanin; D G Spiker; J Neil; P Coble
Journal:  Commun Psychopharmacol       Date:  1979

2.  (Z)-dimethylamino-1-(4-bromophenyl)-1-(3-pyridyl) propene (h 102/09), a new selective inhibitor of the neuronal 5-hydroxytryptamine uptake.

Authors:  S B Ross; S O Ogren; A L Renyi
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1976-08

3.  Reserpine and sleep.

Authors:  J D Coulter; B K Lester; H L Williams
Journal:  Psychopharmacologia       Date:  1971

4.  Interaction of EEG sleep, antidepressants, and affective disease.

Authors:  D Kupfer
Journal:  J Clin Psychiatry       Date:  1982-11       Impact factor: 4.384

5.  Preliminary clinical test of zimelidine (H 102/09), a new 5-HT uptake inhibitor.

Authors:  A Aberg; G Holmberg
Journal:  Acta Psychiatr Scand       Date:  1979-01       Impact factor: 6.392

6.  Imipramine and REM sleep: cholinergic mediation in animals.

Authors:  S Y Hill; R B Reyes; D J Kupfer
Journal:  Psychopharmacology (Berl)       Date:  1980       Impact factor: 4.530

7.  A double blind comparison of zimelidine and amitriptyline in endogenous depression.

Authors:  S A Montgomery; R McAuley; S J Rani; D Roy; D B Montgomery
Journal:  Acta Psychiatr Scand Suppl       Date:  1981

8.  The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor.

Authors:  S O Ogren; S B Ross; H Hall; A C Holm; A L Renyi
Journal:  Acta Psychiatr Scand Suppl       Date:  1981

9.  Zimelidine: comparison of different dosage regimes in general practice.

Authors:  J M Watson; B Tiplady
Journal:  Acta Psychiatr Scand Suppl       Date:  1981

10.  Zimelidine vs maprotiline in depressed outpatients. A preliminary report.

Authors:  G d'Elia; T Hällström; C Nyström; J O Ottosson
Journal:  Acta Psychiatr Scand Suppl       Date:  1981
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  4 in total

1.  Fluoxetine decreases brain temperature and REM sleep in Syrian hamsters.

Authors:  B Gao; W C Duncan; T A Wehr
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Similar effect on REM sleep but differential effect on slow wave sleep of the two 5-HT uptake inhibitors zimeldine and alaproclate in cats and rats.

Authors:  L Sommerfelt; E R Hauge; R Ursin
Journal:  J Neural Transm       Date:  1987       Impact factor: 3.575

3.  Effects of repeated zimelidine administration on sleep parameters in the rat.

Authors:  R B Reyes; S Y Hill; D J Kupfer
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats.

Authors:  L A Hilakivi; D Stenberg; J D Sinclair; K Kiianmaa
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530
  4 in total

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