Literature DB >> 6223528

A double-blind, randomized comparison of moxalactam versus clindamycin-gentamicin in treatment of endomyometritis after cesarean section delivery.

R S Gibbs, J D Blanco, P Duff, Y S Castaneda, P J St Clair.   

Abstract

A double-blind comparison of clindamycin plus gentamicin versus moxalactam plus placebo was performed for the treatment of endomyometritis after cesarean section delivery. Entry criteria were uterine tenderness, temperature greater than or equal to 101 degrees F, and leukocytosis. Uterine specimens were obtained for culture via a single-lumen transcervical catheter. Bacteremia occurred in 10% of patients. Among the 57 patients treated with clindamycin plus gentamicin, there were two clinical failures and four side effect failures (diarrhea in two, allergic reaction in two). Among the 56 patients in the moxalactam group, there were four clinical failures and one side effect failure (diarrhea). Both regimens had good cure rates, with no significant differences in cures or postoperative hospital stay.

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Year:  1983        PMID: 6223528     DOI: 10.1016/0002-9378(83)91075-x

Source DB:  PubMed          Journal:  Am J Obstet Gynecol        ISSN: 0002-9378            Impact factor:   8.661


  5 in total

Review 1.  Antibiotic regimens for postpartum endometritis.

Authors:  A Dhanya Mackeen; Roger E Packard; Erika Ota; Linda Speer
Journal:  Cochrane Database Syst Rev       Date:  2015-02-02

2.  Randomized comparison of ceftazidime versus clindamycin-tobramycin in the treatment of obstetrical and gynecological infections.

Authors:  J D Blanco; R S Gibbs; P Duff; Y S Castaneda; P J St Clair
Journal:  Antimicrob Agents Chemother       Date:  1983-10       Impact factor: 5.191

3.  Prospective cost analysis of moxalactam versus clindamycin plus gentamicin for endomyometritis after cesarean section.

Authors:  L C Knodel; B R Goldspiel; R S Gibbs
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

4.  Comparison of moxalactam and cefazolin as prophylactic antibiotics during cesarean section.

Authors:  W Rayburn; M Varner; R Galask; C R Petzold; E Piehl
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

5.  Role of Bacteroides bivius beta-lactamase in beta-lactam susceptibility.

Authors:  J M Lacroix; F Lamothe; F Malouin
Journal:  Antimicrob Agents Chemother       Date:  1984-11       Impact factor: 5.191

  5 in total

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