Literature DB >> 6222855

Humoral immune response in aged humans: suppressor effect of monocytes on spontaneous plaque forming cell generation.

S Antonaci, E Jirillo, G Lucivero, M Gallitelli, A R Garofalo, L Bonomo.   

Abstract

In 50 old donors antibody synthesis has been detected using a protein A haemolytic plaque assay. Data provide evidence that the plaque forming cell (PFC) capacity of aged peripheral mononuclear cells (PBMC) is significantly depressed (0 . 01 greater than P greater than 0 . 001) in comparison to controls. Additionally, suppression is mediated by adherent cells, since monocyte depleted lymphocytes regain the ability of generating spontaneous plaques. The inhibitory effect of monocytes seems to be prostaglandin-dependent, since indomethacin pre-treated PBMC give rise to a normal number of plaques when compared to young mononuclear cells.

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Year:  1983        PMID： 6222855      PMCID： PMC1535835     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  18 in total

1.  Preparation of human leukocyte interferon for clinical use.

Authors:  K Cantell; S Hirvonen
Journal:  Tex Rep Biol Med       Date:  1977

2.  Age-related changes in the subsets and functions of human T lymphocytes.

Authors:  S Kishimoto; S Tomino; K Inomata; S Kotegawa; T Saito; M Kuroki; H Mitsuya; S Hisamitsu
Journal:  J Immunol       Date:  1978-11       Impact factor: 5.422

3.  Ageing, immune response, and mortality.

Authors:  I C Roberts-Thomson; S Whittingham; U Youngchaiyud; I R Mackay
Journal:  Lancet       Date:  1974-08-17       Impact factor: 79.321

4.  Cytochemical identification of monocytes and granulocytes.

Authors:  L T Yam; C Y Li; W H Crosby
Journal:  Am J Clin Pathol       Date:  1971-03       Impact factor: 2.493

5.  Three suppressor systems in human blood that modulate lymphoproliferation.

Authors:  L Rice; A H Laughter; J J Twomey
Journal:  J Immunol       Date:  1979-03       Impact factor: 5.422

6.  Age-related impairment of the in vitro antibody response in the human.

Authors:  J F Delfraissy; P Galanaud; J Dormont; C Wallon
Journal:  Clin Exp Immunol       Date:  1980-01       Impact factor: 4.330

7.  The dual effect of prostaglandin (PGE2) and ethanol on the natural killer cytolytic process: effector activation and NK-cell-target cell conjugate lytic inhibition.

Authors:  R A Kendall; S Targan
Journal:  J Immunol       Date:  1980-12       Impact factor: 5.422

8.  Pretreatment of plastic Petri dishes with fetal calf serum. A simple method for macrophage isolation.

Authors:  K Kumagai; K Itoh; S Hinuma; M Tada
Journal:  J Immunol Methods       Date:  1979       Impact factor: 2.303

9.  Immunodeficiency and autoimmunity in aging.

Authors:  T Makinodan; M L Heidrick; A A Nordin
Journal:  Birth Defects Orig Artic Ser       Date:  1975

10.  Suppression of human T-cell mitogenesis by prostaglandin. Existence of a prostaglandin-producing suppressor cell.

Authors:  J S Goodwin; A D Bankhurst; R P Messner
Journal:  J Exp Med       Date:  1977-12-01       Impact factor: 14.307
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  1 in total

1.  In vitro effects of human lipoproteins on the immune system in healthy donors: inhibition of plaque forming cell generation and decreased frequency of NK cells.

Authors:  S Antonaci; E Jirillo; M T Ventura; A Capurso; A R Garofalo; L Bonomo
Journal:  Clin Exp Immunol       Date:  1984-06       Impact factor: 4.330
  1 in total

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