Literature DB >> 6222844

Antitumor effects of GANU and other nitrosourea derivatives against transplantable leukemias and solid tumors in mice.

G Sava, T Giraldi.   

Abstract

The antitumor effects of GANU have been examined in a panel of mouse tumors for which data appear to be lacking in the literature. GANU has significant activity against P388 leukemia and TLX5 lymphoma, and also against the solid tumors B16 melanoma and Lewis lung carcinoma; pulmonary metastases of this tumor are particularly sensitive to the effects of GANU. The effects of GANU on TLX5 lymphoma and Lewis lung carcinoma are less pronounced than those of BCNU and CCNU, as already reported for L1210 leukemia. In contrast with other results obtained with this tumor, chlorozotocin has a less pronounced effect than GANU, and virtually none in lung metastases of Lewis lung carcinoma.

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Year:  1983        PMID： 6222844     DOI： 10.1007/bf00255754

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  14 in total

1.  A structure-activity analysis of chemical and biological parameters of chloroethylnitrosoureas in mice.

Authors:  L C Panasci; D Green; R Nagourney; P Fox; P S Schein
Journal:  Cancer Res       Date:  1977-08       Impact factor: 12.701

2.  Comparative studies on the antitumor activity and the bone marrow toxicity of 1-(beta-D-glucopyranosyl)-3-(2-chloroethyl)-3-nitrosourea and 2-(3-(2-chloroethyl)-3-nitrosoureido)-D-glucopyranose.

Authors:  M Aoshima; Y Sakurai
Journal:  Gan       Date:  1977-04

3.  Effect of 1-(2-chloroethyl)-3-(beta-D-glucopyranosyl)-1-nitrosourea on experimental tumors.

Authors:  T Hisamatsu; S Uchida
Journal:  Gan       Date:  1977-12

4.  Preparation and antitumor activity of 1-aryl-3,3-dimethyltriazene derivatives.

Authors:  T Giraldi; C Nisi; T A Connors; P M Goddard
Journal:  J Med Chem       Date:  1977-06       Impact factor: 7.446

Review 5.  An overview of the status of the nitrosoureas in other tumors.

Authors:  S K Carter
Journal:  Cancer Chemother Rep 3       Date:  1973-05

6.  A structure--activity study of seven new water soluble nitrosoureas.

Authors:  J M Heal; P Fox; P S Schein
Journal:  Biochem Pharmacol       Date:  1979-04-15       Impact factor: 5.858

7.  Combination chemotherapy of L1210 mouse leukemia using a new water-soluble nitrosourea, 1-(2-chloroethyl)-3-(beta-d-glucopyranosyl)-1-nitrosourea, with various antimetabolites.

Authors:  E Nagura; A Hoshino; T Sugihara; S Machida
Journal:  Gan       Date:  1980-08

8.  Phase I study of GANU and MCNU.

Authors:  M Ogawa
Journal:  Cancer Treat Rev       Date:  1980-12       Impact factor: 12.111

9.  Antitumor activity of N-diazoacetyl derivatives of glycine and phenylalanine against P388 leukemia and B16 melanoma in mice.

Authors:  G Sava; T Giraldi; L Baldini
Journal:  Cancer Treat Rep       Date:  1982-01

Review 10.  1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: a review.

Authors:  S K Carter; F M Schabel; L E Broder; T P Johnston
Journal:  Adv Cancer Res       Date:  1972       Impact factor: 6.242
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  1 in total

1.  CGP 6809, a sugar-containing nitrosourea derivative: pharmacological and physicochemical properties.

Authors:  K Schieweck; J Stanek; P M Kanter; K H Schmidt-Ruppin; M Müller; A Matter
Journal:  Cancer Chemother Pharmacol       Date:  1989       Impact factor: 3.333
  1 in total

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