Literature DB >> 6222382

Definition of two pathways for generation of suppressor T-cell activity.

S K Hu, D D Eardley, H Cantor, R K Gershon.   

Abstract

Antigen-stimulated Ly1 cells induce T cells from nonimmune donors to develop potent feedback suppressive activity. Suppression is mediated by Ly23 suppressor T (Ts) cells, which are generated from either Ly23 or Ly123 precursors. Ts activity generated from Ly23 precursors requires a strong inducer signal and is rapidly expressed but short lived. In contrast, Ts activity from Ly123 precursors is relatively long lived and is efficiently generated by relatively low levels of inducer signals. Induction of both Ly123 and Ly23 precursors to become Ts cells requires that both cells share genes linked to the Ig-H locus.

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Year:  1983        PMID： 6222382      PMCID： PMC394135          DOI： 10.1073/pnas.80.12.3779

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  "Panning" for lymphocytes: a method for cell selection.

Authors:  L J Wysocki; V L Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

Review 2.  Immunological circuits: cellular composition.

Authors:  H Cantor; R K Gershon
Journal:  Fed Proc       Date:  1979-06

3.  Further improvements in the plaque technique for detecting single antibody-forming cells.

Authors:  A J Cunningham; A Szenberg
Journal:  Immunology       Date:  1968-04       Impact factor: 7.397

4.  Analysis of antigen-specific, Ig-restricted cell-free material made by I-J+ Ly-1 cells (Ly-1 TsiF) that induces Ly-2+ cells to express suppressive activity.

Authors:  K Yamauchi; D Murphy; H Cantor; R K Gershon
Journal:  Eur J Immunol       Date:  1981-11       Impact factor: 5.532

5.  Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

Authors:  H Cantor; E A Boyse
Journal:  J Exp Med       Date:  1975-06-01       Impact factor: 14.307

6.  Immunoregulatory circuits among T-cell sets. Identification of a subpopulation of T-helper cells that induces feedback inhibition.

Authors:  H Cantor; J Hugenberger; L McVay-Boudreau; D D Eardley; J Kemp; F W Shen; R K Gershon
Journal:  J Exp Med       Date:  1978-10-01       Impact factor: 14.307

7.  Genetic control of immunoregulatory circuits. Genes linked to the Ig locus govern communication between regulatory T-cell sets.

Authors:  D D Eardley; F W Shen; H Cantor; R K Gershon
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307

8.  Separation of helper T cells from suppressor T cells expressing different Ly components. II. Activation by antigen: after immunization, antigen-specific suppressor and helper activities are mediated by distinct T-cell subclasses.

Authors:  H Cantor; F W Shen; E A Boyse
Journal:  J Exp Med       Date:  1976-06-01       Impact factor: 14.307

9.  Immunization of dissociated spleen cell cultures from normal mice.

Authors:  R I Mishell; R W Dutton
Journal:  J Exp Med       Date:  1967-09-01       Impact factor: 14.307

10.  Antigen-specific T lymphocyte clones. I. Characterization of a T lymphocyte clone expressing antigen-specific suppressive activity.

Authors:  M Fresno; G Nabel; L McVay-Boudreau; H Furthmayer; H Cantor
Journal:  J Exp Med       Date:  1981-05-01       Impact factor: 14.307
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4.  Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

Authors:  D M Granoff; J P Pandey; E Boies; J Squires; R S Munson; B Suarez
Journal:  J Clin Invest       Date:  1984-11       Impact factor: 14.808

5.  A subset of Ly-1 inducer T cell clones activates B cell proliferation but directly inhibits subsequent IgG secretion.

Authors:  S Friedman; D Sillcocks; A Rao; S Faas; H Cantor
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Review 6.  Different subpopulations of regulatory T cells in human autoimmune disease, transplantation, and tumor immunity.

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