Literature DB >> 6222139

Deficiency in suppressor T cell activity in aged animals. Reconstitution of this activity by interleukin 2.

M L Thoman, W O Weigle.   

Abstract

Spleen cells derived from aged (30 mo) C57Bl/6 mice are shown to be deficient in the ability to generate suppressor cell activity in vitro. The addition of IL-2 to cultures containing aged cells restores this function to a large extent.

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Year:  1983        PMID： 6222139      PMCID： PMC2187056          DOI： 10.1084/jem.157.6.2184

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  26 in total

1.  In vitro generation of suppressor cell activity: suppression of in vitro induction if cell-mediated cytotoxicity.

Authors:  R J Hodes; K S Hathcock
Journal:  J Immunol       Date:  1976-01       Impact factor: 5.422

2.  Regulation of the immune response in autoimmune NZB/NZW F1 mice. I. The spontaneous generation of splenic suppressor cells.

Authors:  J C Roder; D A Bell; S K Singhal
Journal:  Cell Immunol       Date:  1977-03-15       Impact factor: 4.868

3.  A rapid method for the isolation of functional thymus-derived murine lymphocytes.

Authors:  M H Julius; E Simpson; L A Herzenberg
Journal:  Eur J Immunol       Date:  1973-10       Impact factor: 5.532

4.  Presence of impairment of humoral immunity in nonadherent spleen cells of old mice.

Authors:  M L Heidrick; T Makinodan
Journal:  J Immunol       Date:  1973-11       Impact factor: 5.422

5.  Decline in mixed lymphocyte reactivity of spleen cells from aged mice of a long-lived strain.

Authors:  T G Konen; G S Smith; R L Walford
Journal:  J Immunol       Date:  1973-05       Impact factor: 5.422

6.  Humoral immunity in aged mice. II. Increased suppressor T cell activity in immunologically deficient old mice.

Authors:  D Segre; M Segre
Journal:  J Immunol       Date:  1976-03       Impact factor: 5.422

7.  Suppressor lymphocytes in young and aged humans.

Authors:  H M Hallgren; E J Yunis
Journal:  J Immunol       Date:  1977-06       Impact factor: 5.422

8.  Lymphocyte-mediated cytotoxicity: effects of ageing, adult thymectomy and thymic factor.

Authors:  M A Bach
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

9.  Age-related changes in T cell function.

Authors:  R L Krogsrud; E H Perkins
Journal:  J Immunol       Date:  1977-05       Impact factor: 5.422

10.  Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice.

Authors:  E A Goidl; J B Innes; M E Weksler
Journal:  J Exp Med       Date:  1976-10-01       Impact factor: 14.307
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  5 in total

1.  Immune-related alterations in aged gut-associated lymphoid tissues in mice.

Authors:  H Kawanishi; J Kiely
Journal:  Dig Dis Sci       Date:  1989-02       Impact factor: 3.199

2.  Age-dependent appearance of non-major histocompatibility complex-restricted helper T cells.

Authors:  C Russo; E P Cherniack; A Wali; M E Weksler
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

3.  Impaired non-specific suppressor-inducer T-cell activity in aged murine Peyer's patches, which can be corrected largely by IL-2 in vitro.

Authors:  H Kawanishi; J Kiely
Journal:  Immunology       Date:  1989-01       Impact factor: 7.397

4.  Antigen-specific suppressor T cells respond to recombinant interleukin-2 and other lymphokines.

Authors:  C E Taylor; M B Fauntleroy; P W Stashak; P J Baker
Journal:  Infect Immun       Date:  1991-02       Impact factor: 3.441

5.  Suppressor T cell growth and differentiation. Identification of a cofactor required for suppressor T cell function and distinct from interleukin 2.

Authors:  S Rich; M R Carpino; C Arhelger
Journal:  J Exp Med       Date:  1984-05-01       Impact factor: 14.307
  5 in total

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