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Literature DB >> 622161

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine.

G M Sheldrick, P G Jones, O Kennard, D H Williams, G A Smith.

Abstract

Vancomycin, a broad-spectrum antibiotic, inhibits the growth of cell walls by complex formation with peptides terminating in D-alanyl-D-alanine. The structure of vancomycin was determined by X-ray analysis of the degradation product CDP-I. A model of the complex is proposed based on this study and spectroscopic data.

Entities: Chemical

Mesh：

Substances：
Dipeptides
Vancomycin

Year: 1978 PMID： 622161 DOI： 10.1038/271223a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

41 in total

Review 1. Resistance of enterococci to glycopeptides.

Authors: P Courvalin
Journal: Antimicrob Agents Chemother Date: 1990-12 Impact factor: 5.191

2. Different modes of vancomycin and D-alanyl-D-alanine peptidase binding to cell wall peptide and a possible role for the vancomycin resistance protein.

Authors: J R Knox; R F Pratt
Journal: Antimicrob Agents Chemother Date: 1990-07 Impact factor: 5.191

3. Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine.

Authors: H Chen; C C Tseng; B K Hubbard; C T Walsh
Journal: Proc Natl Acad Sci U S A Date: 2001-12-18 Impact factor: 11.205

4. Thermodynamic analysis of the interaction of the antibiotic teicoplanin and its aglycone with cell-wall peptides.

Authors: P Arriaga; J Laynez; M Menendez; J Cañada; F Garcia-Blanco
Journal: Biochem J Date: 1990-01-01 Impact factor: 3.857

Review 5. Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues.

Authors: Akinori Okano; Nicholas A Isley; Dale L Boger
Journal: Chem Rev Date: 2017-04-24 Impact factor: 60.622

6. Sensitive radioimmunoassay for vancomycin.

Authors: K L Fong; D H Ho; L Bogerd; T Pan; N S Brown; L Gentry; G P Bodey
Journal: Antimicrob Agents Chemother Date: 1981-01 Impact factor: 5.191

7. Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin.

Authors: Wei Lu; Markus Oberthür; Catherine Leimkuhler; Junhua Tao; Daniel Kahne; Christopher T Walsh
Journal: Proc Natl Acad Sci U S A Date: 2004-03-18 Impact factor: 11.205