Literature DB >> 6220060

The ontogeny of antigen-presenting cells in fetal thymus evaluated by MLR stimulation.

J H Robinson.   

Abstract

This study demonstrates that cells with the characteristics of antigen-presenting cells (APC) are present in murine thymus from as early as 14 days gestation, around the time that T lymphopoiesis is initiated in the embryo. Thymic APC were identified as la+ adherent cells capable of presenting alloantigens to T cells in MLC. The possible role of these cells in thymocyte differentiation is discussed.

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Year:  1983        PMID： 6220060

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  11 in total

1.  Developmental changes predispose the fetal thymus to positive selection of CD4+CD8- T cells.

Authors:  P J Fairchild; J M Austyn
Journal:  Immunology       Date:  1995-06       Impact factor: 7.397

2.  Population movement and fate of autoreactive V beta 6+ T cells in Mls-1a mice.

Authors:  M Hosono; S Ideyama; J Gyotoku; Y Katsura
Journal:  Immunology       Date:  1993-07       Impact factor: 7.397

Review 3.  Macrophages in the thymus.

Authors:  G W Wood
Journal:  Surv Immunol Res       Date:  1985

4.  T-cell tolerance induced in nude mice grafted with thymic epithelium.

Authors:  J H Robinson; C J Chapman; B E Loveland; R K Jordan
Journal:  Immunology       Date:  1992-02       Impact factor: 7.397

5.  Ontogeny of antigen-presenting activity of haptenized cells in mice: early development of syngeneic T cell-stimulatory cells in thymus.

Authors:  M Hosono; Y Katsura; S Muramatsu
Journal:  Immunology       Date:  1984-01       Impact factor: 7.397

6.  The ontogenetic development of macrophage subpopulations and Ia-positive non-lymphoid cells in gut-associated lymphoid tissue of the rat.

Authors:  E P van Rees; C D Dijkstra; M B van der Ende; E M Janse; T Sminia
Journal:  Immunology       Date:  1988-01       Impact factor: 7.397

7.  Ontogeny of rat thymic dendritic cells.

Authors:  A Vicente; A Varas; L Alonso; M Gómez de Moral; A G Zapata
Journal:  Immunology       Date:  1994-05       Impact factor: 7.397

8.  Ontogeny of rat thymic macrophages. Phenotypic characterization and possible relationships between different cell subsets.

Authors:  A Vicente; A Varas; J Moreno; R Sacedón; E Jiménez; A G Zapata
Journal:  Immunology       Date:  1995-05       Impact factor: 7.397

9.  Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

Authors:  B A Kyewski; C G Fathman; R V Rouse
Journal:  J Exp Med       Date:  1986-02-01       Impact factor: 14.307

10.  Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells.

Authors:  M Inaba; K Inaba; M Hosono; T Kumamoto; T Ishida; S Muramatsu; T Masuda; S Ikehara
Journal:  J Exp Med       Date:  1991-03-01       Impact factor: 14.307
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