Literature DB >> 6220023

High-performance liquid chromatography of pefloxacin and its main active metabolites in biological fluids.

G Montay, Y Blain, F Roquet, A Le Hir.   

Abstract

We describe a high-performance liquid chromatographic (HPLC) method for the analysis of pefloxacin, a new antibacterial agent, in plasma and urine following administration of a therapeutic dose in humans. HPLC assay of pefloxacin and its two main active metabolites in urine is also described. The applicability of the methods to pharmacokinetic studies of pefloxacin in humans is demonstrated.

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Year:  1983        PMID： 6220023     DOI： 10.1016/s0378-4347(00)86139-3

Source DB:  PubMed          Journal:  J Chromatogr


  7 in total

1.  Evaluation of pefloxacin, ofloxacin and ciprofloxacin in the treatment of thirty-nine cases of chronic osteomyelitis.

Authors:  P Dellamonica; E Bernard; H Etesse; R Garraffo; H B Drugeon
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1989-12       Impact factor: 3.267

2.  Metabolism and disposition of amifloxacin in laboratory animals.

Authors:  J A Johnson; D P Benziger
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

3.  Analysis of amifloxacin in plasma and urine by high-pressure liquid chromatography and intravenous pharmacokinetics in rhesus monkeys.

Authors:  L F McCoy; B P Crawmer; D P Benziger
Journal:  Antimicrob Agents Chemother       Date:  1985-05       Impact factor: 5.191

4.  Pharmacokinetics of pefloxacin in renal insufficiency.

Authors:  G Montay; C Jacquot; J Bariety; R Cunci
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

5.  Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans.

Authors:  G Montay; Y Goueffon; F Roquet
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

6.  Pharmacokinetics of pefloxacin and amikacin administered simultaneously to intensive care patients.

Authors:  E Sultan; C Richard; M Pezzano; P Auzepy; E Singlas
Journal:  Eur J Clin Pharmacol       Date:  1988       Impact factor: 2.953

7.  Bactericidal effect of pefloxacin and fosfomycin against Pseudomonas aeruginosa in a rabbit endocarditis model with pharmacokinetics of pefloxacin in humans simulated in vivo.

Authors:  D Bugnon; G Potel; Y Q Xiong; J Caillon; D Navas; C Gras; M F Kergueris; P Le Conte; F Jehl; D Baron; H Drugeon
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-08       Impact factor: 5.103
  7 in total

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