Literature DB >> 6219737

Thermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy.

J H Kinsey, D A Cortese, H B Neel.   

Abstract

Tumor cell killing utilizing hematoporphyrin derivative (HPD) phototherapy was studied in a murine tumor model to assess the relative importance of intratumor temperature in causing the tumoricidal effect. Temperature measurements and tumor killing without HPD strongly suggest that HPD phototherapy as reported previously by other workers has at least partially a hyperthermic effect. Also, it is shown that, in this tumor model, tissue light attenuation restricts the radius of action of the light-HPD interaction to approximately 4 mm.

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Year:  1983        PMID： 6219737

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  7 in total

1.  Influence of a haematoporphyrin derivative on the protoporphyrin IX synthesis and photodynamic effect after 5-aminolaevulinic acid sensitization in human colon carcinoma cells.

Authors:  H Messmann; M Geisler; U Gross; C Abels; R M Szeimies; P Steinbach; R Knüchel; M Doss; J Schölmerich; A Holstege
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

2.  In vivo magnetic resonance imaging of the effects of photodynamic therapy.

Authors:  N J Dodd; J V Moore; D G Poppitt; B Wood
Journal:  Br J Cancer       Date:  1989-08       Impact factor: 7.640

3.  The significance of the nature of the photosensitizer for photodynamic therapy: quantitative and biological studies in the colon.

Authors:  H Barr; A J MacRobert; C J Tralau; P B Boulos; S G Bown
Journal:  Br J Cancer       Date:  1990-11       Impact factor: 7.640

4.  Effects of haematoporphyrin derivative and light in combination with hyperthermia on cells in culture.

Authors:  T Christensen; A Wahl; L Smedshammer
Journal:  Br J Cancer       Date:  1984-07       Impact factor: 7.640

5.  Photodynamic therapy in the normal rat colon with phthalocyanine sensitisation.

Authors:  H Barr; C J Tralau; A J MacRobert; N Krasner; P B Boulos; C G Clark; S G Bown
Journal:  Br J Cancer       Date:  1987-08       Impact factor: 7.640

6.  Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours.

Authors:  D K Kelleher; J Bastian; O Thews; P Vaupel
Journal:  Br J Cancer       Date:  2003-07-21       Impact factor: 7.640

7.  Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer.

Authors:  Gal Shafirstein; David A Bellnier; Emily Oakley; Sasheen Hamilton; Michael Habitzruther; Lawrence Tworek; Alan Hutson; Joseph A Spernyak; Sandra Sexton; Leslie Curtin; Steven G Turowski; Hassan Arshad; Barbara Henderson
Journal:  Br J Cancer       Date:  2018-10-24       Impact factor: 7.640
  7 in total

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