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Literature DB >> 6219114

"Activated" monocytes in gastric cancer patients. II. Suppressor and cytostatic activity in vitro.

W Uracz, B Mytar, M Zembala, I Ruggiero, T Popiela, A Czupryna.

Abstract

The spontaneous nitro-blue tetrazolium (NBT) reduction of monocytes from patients with gastric cancer was assessed and compared with an in vitro monocyte-mediated cytostasis of tumor cell lines and their suppressor activity. The increased NBT reduction correlated with the ability of monocytes to inhibit mitogen-induced normal lymphocyte response and cytostatic activity against L-1210 murine lymphoma cell line. These observations suggest that "activated" monocytes of some cancer patients may play the role of suppressor cells and exert an anti-tumor effect in vitro.

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Year: 1982 PMID： 6219114 DOI： 10.1007/bf00406249

Source DB: PubMed Journal: J Cancer Res Clin Oncol ISSN： 0171-5216 Impact factor: 4.553

18 in total

1. Cytolytic and cytostatic activity on tumor cells of circulating human monocytes.

Authors: A Mantovani; T R Jerrells; J H Dean; R B Herberman
Journal: Int J Cancer Date: 1979-01-15 Impact factor: 7.396

2. Comparison of antiviral and antitumor activity of activated macrophages.

Authors: P S Morahan; L A Glasgow; J L Crane; E R Kern
Journal: Cell Immunol Date: 1977-02 Impact factor: 4.868

Review 3. Activation of mononuclear phagocytes: fact, fancy, and future.

Authors: Z A Cohn
Journal: J Immunol Date: 1978-09 Impact factor: 5.422

4. In vitro activation of a human macrophage-like cell line.

Authors: H S Koren; S J Anderson; J W Larrick
Journal: Nature Date: 1979-05-24 Impact factor: 49.962

5. Depressed in vitro peripheral blood lymphocyte response to mitogens in cancer patients: the role of suppressor cells.

Authors: M Zembala; B Mytar; T Popiela; G L Asherson
Journal: Int J Cancer Date: 1977-05-15 Impact factor: 7.396

6. Characterization of a human macrophage-like cell line stimulated in vitro: a model of macrophage functions.

Authors: J W Larrick; D G Fischer; S J Anderson; H S Koren
Journal: J Immunol Date: 1980-07 Impact factor: 5.422

7. Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice.

Authors: H Kirchner; A V Muchmore; T M Chused; H T Holden; R B Herberman
Journal: J Immunol Date: 1975-01 Impact factor: 5.422

8. Increased monocyte-mediated cytostasis of lymphoid cell lines in breast and lung cancer patients.

Authors: T R Jerrells; J H Dean; G Richardson; G B Cannon; R B Herberman
Journal: Int J Cancer Date: 1979-06-15 Impact factor: 7.396

9. "Activated" monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction.

Authors: W Uracz; A Pituch-Noworolska; M Zembala; T Popiela; A Czupryna
Journal: J Cancer Res Clin Oncol Date: 1982 Impact factor: 4.553