Literature DB >> 6218932

Assay of some endogenous and synthetic sex steroids for tumor-initiating activity in rat liver using the Solt-Farber system.

J Schuppler, J Dammé, R Schulte-Hermann.   

Abstract

Endogenous (estradiol-17 beta; progesterone) and synthetic (ethinyl estradiol; cyproterone acetate; norethindrone acetate; norethynodrel) sex steroids were evaluated for tumor-initiating activity in the rat liver using the Solt-Farber system. All steroids were negative. This provides further evidence that tumor formation in long-term rodent bioassays by these compounds may be due to epigenetic mechanisms.

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Year:  1983        PMID： 6218932     DOI： 10.1093/carcin/4.2.239

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  6 in total

Review 1.  Tumor promotion in the liver.

Authors:  R Schulte-Hermann
Journal:  Arch Toxicol       Date:  1985-08       Impact factor: 5.153

Review 2.  Cyproterone acetate: is it hepato- or genotoxic?

Authors:  T Rabe; K Feldmann; L Heinemann; B Runnebaum
Journal:  Drug Saf       Date:  1996-01       Impact factor: 5.606

3.  The genotoxicity of trenbolone, a synthetic steroid.

Authors:  M Richold
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

4.  Liver structure and function during long-term treatment with cyproterone acetate.

Authors:  E Kaiser; H S Gruner
Journal:  Arch Gynecol       Date:  1987

5.  Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro.

Authors:  M Caviezel; W K Lutz; U Minini; C Schlatter
Journal:  Arch Toxicol       Date:  1984-07       Impact factor: 5.153

6.  3,2'-Dimethyl-4-aminobiphenyl-induced gallbladder carcinogenesis and effects of ethinyl estradiol in hamsters.

Authors:  R Hasegawa; K Ogawa; K Takaba; T Shirai; N Ito
Journal:  Jpn J Cancer Res       Date:  1992-12
  6 in total

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