Literature DB >> 6218826

Inhibition of mitochondrial oxidative phosphorylation by adriamycin.

H Muhammed, T Ramasarma, C K Kurup.   

Abstract

The antitumour antibiotic, adriamycin, inhibited oxidative phosphorylation in freshly prepared mitochondria from the heart, liver and kidney of the rat. It abolished respiratory control and stimulated ATPase activity. Succinate oxidation by heart mitochondria was extremely sensitive to the drug when hexokinase was present in the reaction medium. The sensitive site has been identified to lie in the region between the succinate dehydrogenase flavoprotein and ubiquinone of the respiratory chain.

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Year:  1983        PMID： 6218826     DOI： 10.1016/0005-2728(83)90155-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

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Authors:  O Marcillat; Y Zhang; K J Davies
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4.  Influence of ubiquinone on the inhibitory effect of adriamycin on mitochondrial oxidative phosphorylation.

Authors:  H Muhammed; C K Kurup
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

5.  Uncoupling protein downregulation in doxorubicin-induced heart failure improves mitochondrial coupling but increases reactive oxygen species generation.

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Review 8.  The biochemical basis of mitochondrial diseases.

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9.  Inhibition of plasma membrane NADH dehydrogenase by adriamycin and related anthracycline antibiotics.

Authors:  I L Sun; F L Crane; H Löw; C Grebing
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Review 10.  Anthracycline antibiotics in cancer therapy. Focus on drug resistance.

Authors:  D J Booser; G N Hortobagyi
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  10 in total

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