[Effect of celiprolol, fenoterol and aminophylline on respiratory tract obstruction during an asthma attack].

Selective beta 1-blocking drugs without bronchoconstrictor effect are desirable in patients with bronchial asthma and systemic hypertension or tachycardia. Therefore, 15 patients with bronchial asthma were given a single dose of 100 mg celiprolol (and 5 of them 300 mg) and airway obstruction (Raw, FEV1), pulse rate and blood pressure were documented for 3 hours. After 2 hours an additional infusion of aminophylline and after 3 hours an additional inhalation of fenoterol were given. Within 120 minutes after the intake of celiprolol no statistical changes in the measured data (Raw, FEV1, blood pressure and pulse rate) were found. The same was true after the infusion of aminophylline. Reversibility of airway obstruction by fenoterol was better after celiprolol plus aminophylline than without this premedication (p less than 0.05). It is concluded that the beta 1-antagonist celiprolol does not induce relevant airway obstruction in patients with bronchial asthma, and that an additional infusion of aminophylline enhances the bronchodilatory effect of the beta 2-agonist fenoterol (p less than 0.05).