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Literature DB >> 6215918

Purification and structural studies on the complement-system control protein beta 1H (Factor H).

Abstract

An efficient procedure for the isolation of the complement-system control protein beta 1H (Factor H) from human plasma was developed. The chemical composition and physical characteristics of the protein were studied, and a sequence of 17 amino acid residues at the N-terminus was determined. Factor H is a single-polypeptide-chain glycoprotein of mol.wt. 155 000 containing 9.3% carbohydrate. Factor H is cleaved by plasma proteinases to a two-chain form. This cleavage can be mimicked by trypsin, and the two-chain form retains fully the C3b-inactivator cofactor activity of Factor H. The proteolytic fragments of Factor H are compared with those of other proteins (C4b-binding protein and erythrocyte C3b-receptor) that act as cofactors for C3b-inactivator.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6215918 PMCID： PMC1158480 DOI： 10.1042/bj2050285

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

36 in total

1. An improved purification procedure for the third component of complement and beta 1H globulin from human serum.

Authors: R A Harrison; P J Lachmann
Journal: Mol Immunol Date: 1979-10 Impact factor: 4.407

2. Identification of a major human serum DNA-binding protein as beta 1H of the alternative pathway of complement activation.

Authors: W D Gardner; P J White; S O Hoch
Journal: Biochem Biophys Res Commun Date: 1980-05-14 Impact factor: 3.575

3. Regulation of the amplification C3 convertase of human complement by an inhibitory protein isolated from human erythrocyte membrane.

Authors: D T Fearon
Journal: Proc Natl Acad Sci U S A Date: 1979-11 Impact factor: 11.205

4. The physiological breakdown of the third component of human complement.

Authors: R A Harrison; P J Lachmann
Journal: Mol Immunol Date: 1980-01 Impact factor: 4.407

5. Metabolism of human beta 1H: studies in man and experimental animals.

Authors: J A Charlesworth; D M Scott; B A Pussell; D K Peters
Journal: Clin Exp Immunol Date: 1979-12 Impact factor: 4.330

6. Activation of the alternative pathway of complement: efficient fluid-phase amplification by blockade of the regulatory complement protein beta1H through sulfated polyanions.

Authors: D Bitter-Suermann; R Burger; U Hadding
Journal: Eur J Immunol Date: 1981-04 Impact factor: 5.532

7. High molecular weight complex in human plasma between vitamin K-dependent protein S and complement component C4b-binding protein.

Authors: B Dahlbäck; J Stenflo
Journal: Proc Natl Acad Sci U S A Date: 1981-04 Impact factor: 11.205

8. Complement receptor is an inhibitor of the complement cascade.

Authors: K Iida; V Nussenzweig
Journal: J Exp Med Date: 1981-05-01 Impact factor: 14.307

9. Interaction of beta1H globulin with cell-bound C3b: quantitative analysis of binding and influence of alternative pathway components on binding.

Authors: D H Conrad; J R Carlo; S Ruddy
Journal: J Exp Med Date: 1978-06-01 Impact factor: 14.307

10. The role of C4-binding protein and beta 1H in proteolysis of C4b and C3b.

Authors: T Fujita; V Nussenzweig
Journal: J Exp Med Date: 1979-08-01 Impact factor: 14.307

49 in total

1. Attenuation of renal ischemia and reperfusion injury by human adrenomedullin and its binding protein.

Authors: Kavin G Shah; Derry Rajan; Asha Jacob; Rongqian Wu; Kambhampaty Krishnasastry; Jeffrey Nicastro; Ernesto P Molmenti; Gene F Coppa; Ping Wang
Journal: J Surg Res Date: 2010-04-24 Impact factor: 2.192

2. Use of time-resolved FRET to validate crystal structure of complement regulatory complex between C3b and factor H (N terminus).

Authors: Isabell C Pechtl; Robert K Neely; David T F Dryden; Anita C Jones; Paul N Barlow
Journal: Protein Sci Date: 2011-12 Impact factor: 6.725

3. Activation and binding of opsonic fragments of C3 on encapsulated Cryptococcus neoformans by using an alternative complement pathway reconstituted from six isolated proteins.

Authors: T R Kozel; M A Wilson; G S Pfrommer; A M Schlageter
Journal: Infect Immun Date: 1989-07 Impact factor: 3.441

4. Characterization of binding of human beta 2-glycoprotein I to cardiolipin.

Authors: Z Kertesz; B B Yu; A Steinkasserer; H Haupt; A Benham; R B Sim
Journal: Biochem J Date: 1995-08-15 Impact factor: 3.857

5. Antigenic relationship between the alpha-chain of C3, a leucocyte-surface antigen involved in the activation of phagocytic cells, and a 50,000 MW B-cell antigen.

Authors: T F Schulz; H Scharfenberger; J D Lambris; P Rieber; G Riethmüller; M P Dierich
Journal: Immunology Date: 1985-04 Impact factor: 7.397

6. Interactions between human complement components factor H, factor I and C3b.

Authors: C J Soames; R B Sim
Journal: Biochem J Date: 1997-09-01 Impact factor: 3.857

7. Isolation of two molecular populations of human complement factor H by hydrophobic affinity chromatography.

Authors: J Ripoche; A Al Salihi; J Rousseaux; M Fontaine
Journal: Biochem J Date: 1984-07-01 Impact factor: 3.857

8. Identification of three physically and functionally distinct binding sites for C3b in human complement factor H by deletion mutagenesis.

Authors: A K Sharma; M K Pangburn
Journal: Proc Natl Acad Sci U S A Date: 1996-10-01 Impact factor: 11.205

Review 9. Factor H and neisserial pathogenesis.

Authors: Jo Anne Welsch; Sanjay Ram
Journal: Vaccine Date: 2008-12-30 Impact factor: 3.641

10. The central portion of factor H (modules 10-15) is compact and contains a structurally deviant CCP module.

Authors: Christoph Q Schmidt; Andrew P Herbert; Haydyn D T Mertens; Mara Guariento; Dinesh C Soares; Dusan Uhrin; Arthur J Rowe; Dmitri I Svergun; Paul N Barlow
Journal: J Mol Biol Date: 2009-10-14 Impact factor: 5.469