Literature DB >> 6213279

Constitutive expression of platelet glycoproteins by the human leukemia cell line K562.

A M Gewirtz, D Burger, T A Rado, E J Benz, R Hoffman.   

Abstract

The human leukemia cell line K562 was derived from a patient with chronic granulocytic leukemia. This cell line has subsequently been shown to possess phenotypic markers typical of erythroid and myeloid cells. Using a rabbit antiserum directed against purified platelet glycoproteins (PGPs), we have obtained evidence for the constitutive expression of PGPs on the surface of K562 cells. PGPs expressed have been tentatively identified as IIa and III based on their apparent migration in a 7% sodium dodecylsulfate polyacrylamide gel. K562 may become an important tool for the study of early events involved in megakaryocytic differentiation.

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Year:  1982        PMID： 6213279

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  10 in total

1.  Flow cytometric measurement of rRNA levels detected by fluorescent in situ hybridization in differentiating K-562 cells.

Authors:  L Pajor; J G Bauman
Journal:  Histochemistry       Date:  1991

2.  Localization of the gene for coagulation factor XIII a-chain to chromosome 6 and identification of sites of synthesis.

Authors:  L J Weisberg; D T Shiu; C S Greenberg; Y W Kan; M A Shuman
Journal:  J Clin Invest       Date:  1987-02       Impact factor: 14.808

3.  Developmental programs of human erythroleukemia cells: globin gene expression and methylation.

Authors:  T Enver; J W Zhang; N P Anagnou; G Stamatoyannopoulos; T Papayannopoulou
Journal:  Mol Cell Biol       Date:  1988-11       Impact factor: 4.272

4.  Monocytes and platelets share the glycoproteins IIb and IIIa that are absent from both cells in Glanzmann's thrombasthenia type I.

Authors:  G Gogstad; O Hetland; N O Solum; H Prydz
Journal:  Biochem J       Date:  1983-08-15       Impact factor: 3.857

5.  Human platelets express the SERCA2-b isoform of Ca(2+)-transport ATPase.

Authors:  J Enouf; R Bredoux; B Papp; I Djaffar; A M Lompré; N Kieffer; O Gayet; K Clemetson; F Wuytack; J P Rosa
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

6.  Hematopoietic placental protein 14. An immunosuppressive factor in cells of the megakaryocytic lineage.

Authors:  D M Morrow; N Xiong; R R Getty; M Z Ratajczak; D Morgan; M Seppala; L Riittinen; A M Gewirtz; M L Tykocinski
Journal:  Am J Pathol       Date:  1994-12       Impact factor: 4.307

7.  Phorbol ester induces c-sis gene transcription in stem cell line K-562.

Authors:  O R Colamonici; J B Trepel; C A Vidal; L M Neckers
Journal:  Mol Cell Biol       Date:  1986-05       Impact factor: 4.272

8.  Expression of platelet membrane glycoproteins and alpha-granule proteins by a human erythroleukemia cell line (HEL).

Authors:  A Tabilio; J P Rosa; U Testa; N Kieffer; A T Nurden; M C Del Canizo; J Breton-Gorius; W Vainchenker
Journal:  EMBO J       Date:  1984-02       Impact factor: 11.598

9.  Naringenin suppresses K562 human leukemia cell proliferation and ameliorates Adriamycin-induced oxidative damage in polymorphonuclear leukocytes.

Authors:  Rui-Fang Li; Ying-Qian Feng; Jun-Hui Chen; Lin-Tong Ge; Shu-Yuan Xiao; Xue-Lan Zuo
Journal:  Exp Ther Med       Date:  2015-01-16       Impact factor: 2.447

10.  Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa.

Authors:  P J Newman; Y Kawai; R R Montgomery; T J Kunicki
Journal:  J Cell Biol       Date:  1986-07       Impact factor: 10.539
  10 in total

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