Literature DB >> 6211996

Antibiotic management of surgically treated gangrenous or perforated appendicitis. Comparison of gentamicin and clindamycin versus cefamandole versus cefoperazone.

T V Berne, A W Yellin, M D Appleman, P N Heseltine.   

Abstract

A study of 130 adult patients with surgically treated gangrenous or perforated appendicitis was undertaken to evaluate the efficacy of three antibiotic regimens. Forty-eight patients received cefamandole, 40 were given the combination of clindamycin and gentamicin, and 42 were treated with cefoperazone. Side effects from these antibiotics were infrequent and mild. When all cases were compared for infectious failure, clindamycin-gentamicin showed a clear advantage over cefamandole. Because of the heterogeneity of the total study population, patients with perforation and peritonitis were compared separately. This analysis confirmed the advantage of clindamycin-gentamicin over cefamandole. In addition, it appears that clindamycin-gentamicin is more efficacious than cefoperazone.

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Year:  1982        PMID： 6211996     DOI： 10.1016/0002-9610(82)90594-3

Source DB:  PubMed          Journal:  Am J Surg        ISSN： 0002-9610            Impact factor:   2.565


  22 in total

Review 1.  Current antimicrobial therapy of anaerobic infections.

Authors:  C V Sanders; K E Aldridge
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1992-11       Impact factor: 3.267

2.  Antibiotic treatment for surgical peritonitis.

Authors:  D L Dunn
Journal:  Ann Surg       Date:  1991-11       Impact factor: 12.969

3.  Susceptibility of Klebsiella pneumoniae isolates from intra-abdominal infections and molecular characterization of ertapenem-resistant isolates.

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4.  Canadian practice guidelines for surgical intra-abdominal infections.

Authors:  Anthony W Chow; Gerald A Evans; Avery B Nathens; Chad G Ball; Glen Hansen; Godfrey Km Harding; Andrew W Kirkpatrick; Karl Weiss; George G Zhanel
Journal:  Can J Infect Dis Med Microbiol       Date:  2010       Impact factor: 2.471

5.  Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate.

Authors:  K I Plaisance; G L Drusano; A Forrest; R J Townsend; H C Standiford
Journal:  Antimicrob Agents Chemother       Date:  1989-05       Impact factor: 5.191

6.  Surgically treated gangrenous or perforated appendicitis. A comparison of aztreonam and clindamycin versus gentamicin and clindamycin.

Authors:  T V Berne; A E Yellin; M D Appleman; M A Gill; F C Chenella; P N Heseltine
Journal:  Ann Surg       Date:  1987-02       Impact factor: 12.969

Review 7.  Role of aminoglycoside antibiotics in the treatment of intra-abdominal infection.

Authors:  J L Ho; M Barza
Journal:  Antimicrob Agents Chemother       Date:  1987-04       Impact factor: 5.191

8.  The bacteriology of gangrenous and perforated appendicitis--revisited.

Authors:  R S Bennion; E J Baron; J E Thompson; J Downes; P Summanen; D A Talan; S M Finegold
Journal:  Ann Surg       Date:  1990-02       Impact factor: 12.969

Review 9.  Antibiotic trials in intra-abdominal infections. A critical evaluation of study design and outcome reporting.

Authors:  J S Solomkin; J L Meakins; M D Allo; E P Dellinger; R L Simmons
Journal:  Ann Surg       Date:  1984-07       Impact factor: 12.969

Review 10.  Are there patients with peritonitis who require empiric therapy for enterococcus?

Authors:  S Harbarth; I Uckay
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2004-01-21       Impact factor: 3.267
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