Literature DB >> 6211765

Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems.

S H Ackerman.   

Abstract

Gastric acid secretion has been thought to depend on histamine stimulation of the parietal cell. However, in the 2-week-old rat neither exogenous histamine nor the H-2 receptor agonist impromidine stimulates acid secretion, whereas pentagastrin and the cholinergic agent bethanechol are potent stimuli. At this age, the effect of pentagastrin in acid secretion is not blocked by the H-2 receptor antagonist cimetidine, nor is it potentiated by impromidine. These data suggest that, in the rat pup, the acid secretory response to pentagastrin and cholinergic agents occurs before the histamine-mediated system is functional and operates independently of the actions of histamine.

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Year:  1982        PMID： 6211765     DOI： 10.1126/science.6211765

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Gastrin, somatostatin, and experimental disturbance of the gastrointestinal tract in rats.

Authors:  Y L Yao; B Xu; W D Zhang; Y G Song
Journal:  World J Gastroenterol       Date:  2001-06       Impact factor: 5.742

2.  Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach.

Authors:  Jie Xu; Penghong Song; Marian L Miller; Frank Borgese; Sharon Barone; Brigitte Riederer; Zhaohui Wang; Seth L Alper; John G Forte; Gary E Shull; Jordi Ehrenfeld; Ursula Seidler; Manoocher Soleimani
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-12       Impact factor: 11.205

3.  Ontogeny of histamine-immunoreactive cells in rat stomach.

Authors:  M J Nissinen; R Håkanson; P Panula
Journal:  Cell Tissue Res       Date:  1992-02       Impact factor: 5.249

4.  Effects of cannabinoid receptor agonists on rat gastric acid secretion: discrepancy between in vitro and in vivo data.

Authors:  Gabriella Coruzzi; Maristella Adami; Elena Guaita; Alessandro Menozzi; Simone Bertini; Elena Giovannini; Giulio Soldani
Journal:  Dig Dis Sci       Date:  2006-02       Impact factor: 3.199

5.  Development of sodium and chloride transport across fetal and newborn rat stomach in vitro.

Authors:  R Ducroc; B Garzon; J P Geloso; F Hervatin; P Millet; E Moreau
Journal:  J Physiol       Date:  1988-04       Impact factor: 5.182

6.  Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells.

Authors:  Atsushi Tamura; Shojiro Kikuchi; Masaki Hata; Tatsuya Katsuno; Takeshi Matsui; Hisayoshi Hayashi; Yuichi Suzuki; Tetsuo Noda; Shoichiro Tsukita; Sachiko Tsukita
Journal:  J Cell Biol       Date:  2005-04-04       Impact factor: 10.539

Review 7.  The pathways regulating acid secretion: the view from the isolated cell.

Authors:  C N Chuang; M C Chen; A H Soll
Journal:  Yale J Biol Med       Date:  1994 May-Aug

Review 8.  Regulation of histamine release from oxyntic mucosa.

Authors:  C N Chuang; M C Chen; A H Soll
Journal:  Yale J Biol Med       Date:  1992 Nov-Dec
  8 in total

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