| Literature DB >> 62112 |
J Brostoff, J F Mowbray, A Kapoor, S J Hollowell, M Rudolf, K B Saunders.
Abstract
Of 26 patients with intrinsic asthma, 21 (81%) were homozygous for the histocompatibility antigen HLA-W6. Also, half the patients had complement defects, in particular low levels of C2. This is the first indication of a strong genetic component in intrinsic asthma, apart from that already known from family studies. These findings suggest that intrinsic asthma may be a recessive disease.Entities:
Mesh：
Substances：
Year: 1976 PMID： 62112 DOI： 10.1016/s0140-6736(76)90537-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321