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Literature DB >> 6210562

Mezlocillin dose dependent elimination kinetics in renal impairment.

G R Aronoff, R S Sloan, R A Stanish, N S Fineberg.

Abstract

The effect of drug dose on mezlocillin elimination kinetics was examined in six subjects with normal renal function and in six anuric patients. Each subject received mezlocillin 1,3 and 5 g as single intravenous doses separated by one week. Elimination was not prolonged by increasing the dose in subjects with normal renal function, but elimination kinetics were dose dependent in anuric patients. Therapeutic guidelines are suggested.

Entities: Chemical Disease Species

Mesh：

Substances：
Penicillins
Mezlocillin

Year: 1982 PMID： 6210562 DOI： 10.1007/bf00542046

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

7 in total

1. Mezlocillin: in vitro studies of a new broad-spectrum penicillin.

Authors: G P Bodey; T Pan
Journal: Antimicrob Agents Chemother Date: 1977-01 Impact factor: 5.191

2. Mezlocillin pharmacokinetics in renal impairment.

Authors: G R Aronoff; R S Sloan; F C Luft; R L Nelson; D R Maxwell; S A Kleit
Journal: Clin Pharmacol Ther Date: 1980-10 Impact factor: 6.875

3. Pharmacokinetics of mezlocillin in healthy volunteers.

Authors: T Bergan
Journal: Antimicrob Agents Chemother Date: 1978-12 Impact factor: 5.191

4. Kinetics of mezlocillin and carbenicillin.

Authors: S J Pancoast; H C Neu
Journal: Clin Pharmacol Ther Date: 1978-07 Impact factor: 6.875

5. [In vitro activity of mezlocillin, azlocillin and carbenicillin against bacteroidaceae with particular reference to bacteroides fragilis (author's transl)].

Authors: H Werner; C Krassemann; J Ungerechts; H J Schmitz
Journal: Infection Date: 1977 Impact factor: 3.553

6. Azlocillin and mezlocillin: new ureido penicillins.

Authors: K P Fu; H C Neu
Journal: Antimicrob Agents Chemother Date: 1978-06 Impact factor: 5.191

7. Mezlocillin pharmacokinetics in patients with normal and impaired renal functions.

Authors: T Bergan; E K Brodwall; E Wiik-Larsen
Journal: Antimicrob Agents Chemother Date: 1979-11 Impact factor: 5.191

7 in total

5 in total

Review 1. High dose treatment with antibiotics in cystic fibrosis--a reappraisal with special reference to the pharmacokinetics of beta-lactams and new fluoroquinolones in adult CF-patients.

Authors: F Sörgel; U Stephan; H G Wiesemann; B Gottschalk; C Stehr; M Rey; H B Böwing; H C Dominick; M Geldmacher von Mallinckrodt
Journal: Infection Date: 1987 Impact factor: 3.553

Mezlocillin dose dependent elimination kinetics in renal impairment.

1. Mezlocillin: in vitro studies of a new broad-spectrum penicillin.

2. Mezlocillin pharmacokinetics in renal impairment.

3. Pharmacokinetics of mezlocillin in healthy volunteers.

4. Kinetics of mezlocillin and carbenicillin.

5. [In vitro activity of mezlocillin, azlocillin and carbenicillin against bacteroidaceae with particular reference to bacteroides fragilis (author's transl)].

6. Azlocillin and mezlocillin: new ureido penicillins.

7. Mezlocillin pharmacokinetics in patients with normal and impaired renal functions.

Review 1. High dose treatment with antibiotics in cystic fibrosis--a reappraisal with special reference to the pharmacokinetics of beta-lactams and new fluoroquinolones in adult CF-patients.

Review 2. Clinical pharmacokinetics of antibiotics in patients with impaired renal function.

3. Effect of dose on pharmacokinetics and serum bactericidal activity of mezlocillin.

4. Comparative pharmacokinetics of two multiple-dose mezlocillin regimens in normal volunteers.

5. The effect of piperacillin dose on elimination kinetics in renal impairment.