Literature DB >> 6210088

The action of substance P on contraction, inositol phospholipids and adenylate cyclase in rat small intestine.

S P Watson.   

Abstract

The actions of substance P and eledoisin on contraction, [3H]inositol 1-phosphate and cAMP formation in the rat ileum have been compared. Eledoisin was considerably more potent than substance P on both contraction and [3H]inositol 1-phosphate production. Neither peptide altered the cAMP levels in the tissue. These results are discussed in relation to the substance P receptor sub-type present in the rat ileum, and its second messenger.

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Year:  1984        PMID： 6210088     DOI： 10.1016/0006-2952(84)90033-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  3 in total

1.  Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder.

Authors:  D R Bristow; N R Curtis; N Suman-Chauhan; K J Watling; B J Williams
Journal:  Br J Pharmacol       Date:  1987-01       Impact factor: 8.739

2.  Homologous desensitization of substance-P-induced inositol polyphosphate formation in rat parotid acinar cells.

Authors:  H Sugiya; K A Tennes; J W Putney
Journal:  Biochem J       Date:  1987-06-15       Impact factor: 3.857

3.  Neurokinin3-receptors are linked to inositol phospholipid hydrolysis in the guinea-pig ileum longitudinal muscle-myenteric plexus preparation.

Authors:  S Guard; K J Watling; S P Watson
Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739
  3 in total

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