| Literature DB >> 6210082 |
C J de Groot, A J van Zonneveld, P G Mooren, D Zonneveld, A van den Dool, A J van den Bogaert, W H Lamers, A F Moorman, R Charles.
Abstract
The construction and cloning of a cDNA complementary to the mRNA of rat liver carbamoylphosphate synthetase (ammonia) is described. Using this cDNA, the size of the mature, cytosolic carbamoylphosphate synthetase (ammonia) mRNA is estimated to be 6.0 Kb. The levels of carbamoylphosphate synthetase (ammonia) mRNA in liver are shown to be regulated by glucocorticosteroids and cyclic AMP. By studying mRNA levels of carbamoylphosphate synthetase, albumin and phosphoenolpyruvate carboxykinase, using specific cDNA clones, we show that carbamoylphosphate synthetase gene expression, like that of albumin is liver-specific.Entities:
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Year: 1984 PMID： 6210082 DOI： 10.1016/0006-291x(84)91040-4
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575