Literature DB >> 6209241

Rat CNS cell culture. Enhancement of neuronal survival and delay of glial proliferation by serum from patients with multiple sclerosis. A morphological study.

G Savettieri, D Ferraro, A Chiarini, A Cestelli.   

Abstract

The addition of serum from multiple sclerosis (MS) patients to the culture medium of dissociated cells from cerebral hemispheres of rat embryos caused a delay in glial proliferation and an enhancement of neuronal survival. Sera from normal individuals and patients with other neurological diseases failed to show this effect. These morphological observations are interpreted as the outcome of inhibition of in vitro gliogenesis.

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Year:  1984        PMID: 6209241     DOI: 10.1007/bf02043964

Source DB:  PubMed          Journal:  Ital J Neurol Sci        ISSN: 0392-0461


  11 in total

1.  A tissue-culture approach to demyelinative disorders.

Authors:  M B BORNSTEIN
Journal:  Natl Cancer Inst Monogr       Date:  1963-03

2.  an in vitro gliotoxic effect of serum from animals with experimental allergic encephalomyelitis.

Authors:  O BERG; B KALLEN
Journal:  Acta Pathol Microbiol Scand       Date:  1962

3.  Complement-dependent serum: neuroelectric blocking activity in multiple sclerosis.

Authors:  C L Schauf; V Schauf; F A Davis; M R Mizen
Journal:  Neurology       Date:  1978-05       Impact factor: 9.910

4.  Simultaneous separation and purification of neurofilament and glial filament proteins from brain.

Authors:  R Liem
Journal:  J Neurochem       Date:  1982-01       Impact factor: 5.372

5.  Growth of purified astrocytes in a chemically defined medium.

Authors:  R S Morrison; J de Vellis
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205

6.  Multiple specificities of antibrain antibodies in multiple sclerosis and chronic myelopathy.

Authors:  B Ryberg
Journal:  J Neurol Sci       Date:  1978-10       Impact factor: 3.181

7.  Antibodies to oligodendroglia in patients with multiple sclerosis.

Authors:  O Abramsky; R P Lisak; D H Silberberg; D E Pleasure
Journal:  N Engl J Med       Date:  1977-12-01       Impact factor: 91.245

8.  Oligodendrocyte staining by multiple sclerosis serum is nonspecific.

Authors:  U Traugott; S Snyder; C S Raine
Journal:  Ann Neurol       Date:  1979-07       Impact factor: 10.422

9.  A search for antibodies against glial cells in the serum and cerebrospinal fluid of patients with multiple sclerosis and Guillain-Barré syndrome.

Authors:  P G Kennedy; R P Lisak
Journal:  J Neurol Sci       Date:  1979-12       Impact factor: 3.181

10.  Do patients with demyelinating disease have antibodies against human glial cells in their sera?

Authors:  P G Kennedy; R P Lisak
Journal:  J Neurol Neurosurg Psychiatry       Date:  1981-02       Impact factor: 10.154

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