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An investigation of the actions of the calcium entry facilitator Bay K 8644 on the rat vas deferens.

Abstract

The pre- and postsynaptic actions of the calcium entry facilitator Bay K 8644 were investigated in the rat isolated vas deferens. Bay K 8644 had no presynaptic effect on adrenergic neurotransmission in the epididymal portion. Bay K 8644 and alpha 1-adrenoceptor agonists potentiated, and the calcium entry blocker nifedipine abolished, the non-adrenergic contraction to a single stimulus in prostatic portions. Bay K 8644 sensitised the prostatic portion to, but did not increase the maximum height of, spontaneous direct contractions produced by alpha-agonists.

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Year: 1984 PMID： 6209150 DOI： 10.1016/0014-2999(84)90414-x

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

An investigation of the actions of the calcium entry facilitator Bay K 8644 on the rat vas deferens.

1. Differential effects of Ca antagonists on the noradrenaline release and contraction evoked by nerve stimulation in the presence of 4-aminopyridine.

2. Differential blocking actions of idazoxan against the inhibitory effects of 6-fluoronoradrenaline and clonidine in the rat vas deferens.

3. Effects of nifedipine and ryanodine on adrenergic neurogenic contractions of rat vas deferens: evidence for a pulse-to-pulse change in Ca2+ sources.

4. Possible involvement of both N- and L-type voltage-dependent Ca channels in adrenergic neurotransmission of canine saphenous veins in low Ca2+ plus tetraethylammonium medium.

5. An investigation of alpha-adrenoceptor responsiveness in the vas deferens of spontaneously hypertensive rats.