Literature DB >> 620908

Effect of one-month treatment with cimetidine on gastric secretion and serum gastrin and pepsinogen levels.

K F Sewing, L Hagie, A F Ippoliti, J I Isenberg, I M Samloff, R A Sturdevant.   

Abstract

The inhibitory effects of cimetidine on gastric acid and pepsin secretion were studied before and after 1 month of treatment with 300 mg of cimetidine four times a day in 15 male duodenal ulcer patients. Cimetidine inhibited both pentagastrin- and peptone meal-stimulated acid secretion significantly better before, than after, 1 month of treatment. Similarly cimetidine inhibited pentagastrin-stimulated pepsin secretion significantly better before treatment. Meal-stimulated serum gastrin concentrations were significantly higher after treatment. The mechanism(s) of these effects was not apparent.

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Year:  1978        PMID： 620908

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  11 in total

1.  Lafutidine, a newly developed antiulcer drug, elevates postprandial intragastric pH and increases plasma calcitonin gene-related peptide and somatostatin concentrations in humans: comparisons with famotidine.

Authors:  Tomohiko Shimatani; Masaki Inoue; Tomoko Kuroiwa; Jing Xu; Masuo Nakamura; Susumu Tazuma; Kazuro Ikawa; Norifumi Morikawa
Journal:  Dig Dis Sci       Date:  2006-01       Impact factor: 3.199

2.  Tolerance to oral H2-receptor antagonists.

Authors:  C H Wilder-Smith; T Ernst; M Gennoni; B Zeyen; F Halter; H S Merki
Journal:  Dig Dis Sci       Date:  1990-08       Impact factor: 3.199

3.  Effects of long-term cimetidine on serum gastrin in duodenal ulcer.

Authors:  J Hansky; A I Stern; M G Korman; J Waugh
Journal:  Dig Dis Sci       Date:  1979-06       Impact factor: 3.199

4.  Effect of H2-receptor antagonists, cimetidine and YM-11170, on serum gastrin levels in lumen-perfused rats.

Authors:  K Ohe; M Nakamura; T Fujiwara; H Matsumoto; M Kohchi; A Miyoshi
Journal:  Dig Dis Sci       Date:  1983-11       Impact factor: 3.199

5.  A controlled study comparing cimetidine treatment to an intensive antacid regimen in the therapy of uncomplicated duodenal ulcer.

Authors:  G Fedeli; M Anti; G L Rapaccini; I De Vitis; A Butti; I M Civello
Journal:  Dig Dis Sci       Date:  1979-10       Impact factor: 3.199

6.  Up-regulation of H2 receptor and adenylate cyclase in rabbit parietal cells during prolonged treatment with H2-receptor antagonists.

Authors:  K Takeuchi; M Kajimura; M Kodaira; S Lin; H Hanai; E Kaneko
Journal:  Dig Dis Sci       Date:  1999-08       Impact factor: 3.199

Review 7.  Antisecretory and antigastrin effects of rioprostil in gastric fistula dogs.

Authors:  L B Katz; T Genna; G H Greeley; D A Shriver
Journal:  Dig Dis Sci       Date:  1987-11       Impact factor: 3.199

8.  A long lasting gastrin response to apomorphine revealed by inhibitors of gastric acid secretion.

Authors:  M Goiny; K Brodin; C E Elwin; K Uvnäs-Moberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-07       Impact factor: 3.000

9.  Gastric secretory conditions and plasma gastrin levels in rats after prolonged treatment with cimetidine.

Authors:  K Tabata; S Okabe
Journal:  Dig Dis Sci       Date:  1984-01       Impact factor: 3.199

10.  Chronic protracted diarrhea and jejunal atrophy in an infant. Cimetidine-associated stimulation of jejunal mucosal growth.

Authors:  S E Fisher; J T Boyle; P Holtzapple
Journal:  Dig Dis Sci       Date:  1981-02       Impact factor: 3.199
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