Literature DB >> 6208758

Single agent therapy of interferon for brain tumours: correlation between natural killer activity and clinical course.

S Otsuka, H Handa, J Yamashita, K Suda, J Takeuchi.   

Abstract

The anti-tumour effect of mouse interferon (IFN) on an intracranially transplanted 203-glioma in C 57BL mice and the natural killer (NK) activity of spleen cells were studied. As a clinical trial, five patients with glioblastomas were treated with human fibroblast IFN and the anti-tumour effect of IFN and the NK activity of peripheral blood lymphocytes were also studied. The NK activity increased after the beginning of IFN therapy but there was no remarkable anti-tumour effect of IFN in both mouse and human studies. There was no marked correlation between the increased NK activity and the anti-tumour effect of IFN in this study.

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Year:  1984        PMID： 6208758     DOI： 10.1007/bf01401780

Source DB:  PubMed          Journal:  Acta Neurochir (Wien)        ISSN： 0001-6268            Impact factor:   2.216


  18 in total

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Authors:  A ISAACS; J LINDENMANN
Journal:  Proc R Soc Lond B Biol Sci       Date:  1957-09-12

2.  Enhancement by interferon of natural killer cell activity in mice.

Authors:  A Senik; I Gresser; C Maury; M Gidlund; A Orn; H Wigzell
Journal:  Cell Immunol       Date:  1979-04       Impact factor: 4.868

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Authors:  P Lindahl; P Leary; I Gresser
Journal:  Proc Natl Acad Sci U S A       Date:  1972-03       Impact factor: 11.205

4.  [Natural killer activity of peripheral blood lymphocytes in patients with brain tumors].

Authors:  S Otsuka; K Suda; J Yamashita; J Takeuchi; H Handa
Journal:  No Shinkei Geka       Date:  1982-12

5.  [Changes of natural killer activity following local 60Co irradiation in intracranial tumor-bearing mice (author's transl)].

Authors:  S Otsuka; K Suda; J Yamashita; J Takeuchi; H Handa
Journal:  No To Shinkei       Date:  1982-04

6.  Interferon and murine leukemia. VII. Therapeutic effect of interferon preparations after diagnosis of lymphoma in AKR mice.

Authors:  I Gresser; C Maury; M Tovey
Journal:  Int J Cancer       Date:  1976-05-15       Impact factor: 7.396

7.  Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture.

Authors:  H Strander; S Einhorn
Journal:  Int J Cancer       Date:  1977-04-15       Impact factor: 7.396

8.  [Clinical effects of human fibroblast interferon on malignant tumors].

Authors:  K Ezaki; K Okabe; J Inagaki; N Horikoshi; K Inoue; K Aiba; M Domyo; T Nagata; M Ogawa
Journal:  Gan To Kagaku Ryoho       Date:  1982-01

9.  [Clinical effect of human fibroblast interferon on malignant cancer. (2) Immunological study of the patients under treatment].

Authors:  K Ezaki; K Okabe; M Domyo; K Abe; M Ogawa
Journal:  Gan To Kagaku Ryoho       Date:  1982-02

10.  Anti-viral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells to lysis.

Authors:  G Trinchieri; D Santoli
Journal:  J Exp Med       Date:  1978-05-01       Impact factor: 14.307
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  4 in total

1.  Local immunotherapy (beta-IFN) and systemic chemotherapy in primary glial tumors.

Authors:  A Boiardi; A Silvani; I Milanesi; L Munari; G Broggi; M Botturi
Journal:  Ital J Neurol Sci       Date:  1991-04

Review 2.  Neuro-oncology index and review (adult primary brain tumors). Radiotherapy, chemotherapy, immunotherapy, photodynamic therapy.

Authors:  M S Mahaley
Journal:  J Neurooncol       Date:  1991-10       Impact factor: 4.130

3.  Intratumoural and intraventricular human lymphoblastoid alpha interferon (HLBI) for treatment of glioblastoma multiforme.

Authors:  R Martínez; J Vaquero; J Ramiro; F García Salazar; S De Oya
Journal:  Acta Neurochir (Wien)       Date:  1989       Impact factor: 2.216

4.  Evaluation of blood-brain barrier permeability and the effect of interferon in mouse glioma model.

Authors:  M Wiranowska; A A Gonzalvo; S Saporta; O R Gonzalez; L D Prockop
Journal:  J Neurooncol       Date:  1992-11       Impact factor: 4.130
  4 in total

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