Literature DB >> 6208489

SCH 23390 blocks D-1 and D-2 dopamine receptors in rat neostriatum in vitro.

J F Plantjé, F J Daus, H A Hansen, J C Stoof.   

Abstract

The agonistic and antagonistic effects of the new compound SCH 23390 were tested in functional model systems for the D-1 dopamine receptor and for the D-2 dopamine receptor in vitro. In superfused rat neostriatal slices the increase in the efflux of cyclic AMP was used as a parameter for D-1 receptor stimulation. D-2 receptor stimulation was measured as the decrease in the K+-evoked release of [3H]-acetylcholine. SCH 23390 had no agonistic activity in these two models. SCH 23390 was a potent antagonist of the stimulating effect of dopamine in the D-1 receptor model (apparent pA2 = 7.28). SCH 23390 also antagonized the effect of the D-2 receptor agonist LY 141865 in the D-2 receptor model (apparent pA2 = 6.34). This D-2 receptor antagonism proved to be of a competitive nature.

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Year:  1984        PMID： 6208489     DOI： 10.1007/bf00500914

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  11 in total

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Authors:  G Brooker; J F Harper; W L Terasaki; R D Moylan
Journal:  Adv Cyclic Nucleotide Res       Date:  1979

Review 2.  Multiple receptors for dopamine.

Authors:  J W Kebabian; D B Calne
Journal:  Nature       Date:  1979-01-11       Impact factor: 49.962

3.  SCH 23390 - the first selective dopamine D-1 antagonist.

Authors:  J Hyttel
Journal:  Eur J Pharmacol       Date:  1983-07-15       Impact factor: 4.432

4.  Opposing roles for D-1 and D-2 dopamine receptors in efflux of cyclic AMP from rat neostriatum.

Authors:  J C Stoof; J W Kebabian
Journal:  Nature       Date:  1981-11-26       Impact factor: 49.962

5.  Further evidence for the involvement of D2, but not D1 dopamine receptors in dopaminergic control of striatal cholinergic transmission.

Authors:  B Scatton
Journal:  Life Sci       Date:  1982-12-20       Impact factor: 5.037

6.  The striatal cholinergic interneuron: synaptic target of dopaminergic terminals?

Authors:  J Lehmann; S Z Langer
Journal:  Neuroscience       Date:  1983-12       Impact factor: 3.590

7.  Evidence that LY-141865 specifically stimulates the D-2 dopamine receptor.

Authors:  K Tsuruta; E A Frey; C W Grewe; T E Cote; R L Eskay; J W Kebabian
Journal:  Nature       Date:  1981-07-30       Impact factor: 49.962

8.  Independent in vitro regulation by the D-2 dopamine receptor of dopamine-stimulated efflux of cyclic AMP and K+-stimulated release of acetylcholine from rat neostriatum.

Authors:  J C Stoof; J W Kebabian
Journal:  Brain Res       Date:  1982-11-04       Impact factor: 3.252

9.  Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus.

Authors:  K Starke; L Späth; J D Lang; C Adelung
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1983-08       Impact factor: 3.000

10.  Dopaminergic mechanisms in the teleost retina. I. Dopamine-sensitive adenylate cyclase in homogenates of carp retina; effects of agonists, antagonists, and ergots.

Authors:  K J Watling; J E Dowling
Journal:  J Neurochem       Date:  1981-02       Impact factor: 5.372
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  11 in total

1.  The effect of intrastriatal application of directly and indirectly acting dopamine agonists and antagonists on the in vivo release of acetylcholine measured by brain microdialysis. The importance of the post-surgery interval.

Authors:  P De Boer; G Damsma; Q Schram; J C Stoof; J Zaagsma; B H Westerink
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-02       Impact factor: 3.000

2.  Activation of dopamine D1 receptors does not affect D2 receptor-mediated inhibition of acetylcholine release in rabbit striatum.

Authors:  V Dolezal; R Jackisch; G Hertting; C Allgaier
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-01       Impact factor: 3.000

3.  Characterization of the dopamine receptor mediating the hyperpolarization of cockroach salivary gland acinar cells in vitro.

Authors:  A M Evans; K L Green
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

4.  Presynaptic regulation of the electrically evoked release of endogenous dopamine from the isolated neurointermediate lobe or isolated neural lobe of the rat pituitary gland in vitro.

Authors:  K Racké; A Grosshans; S Sirrenberg; K Ziegler
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-05       Impact factor: 3.000

5.  In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH23390.

Authors:  S Hjorth; A Carlsson
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

6.  Blockade of gamma-aminobutyric acid-receptors of the B-subtype inhibits the dopamine-induced enhancement of the release of cholecystokinin-like immunoreactivity from slices of rat dorsal caudatoputamen.

Authors:  U Conzelmann; D K Meyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

7.  Opposing role of dopamine D1 and D2 receptors in modulation of rat nucleus accumbens noradrenaline release.

Authors:  L J Vanderschuren; G Wardeh; T J De Vries; A H Mulder; A N Schoffelmeer
Journal:  J Neurosci       Date:  1999-05-15       Impact factor: 6.167

8.  Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213.

Authors:  M T Pugh; K M O'Boyle; A G Molloy; J L Waddington
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

9.  Dopaminergic modulation of hippocampal noradrenaline release. Evidence for alpha 2-antagonistic effects of some dopamine receptor agonists and antagonists.

Authors:  R Jackisch; S Moll; T J Feuerstein; G Hertting
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-08       Impact factor: 3.000

10.  Dopaminergic neurotransmission in somatodendritic and terminal areas of the rat brain: susceptibility to modulation by D1 and D2 receptors and to axotomy.

Authors:  H Nissbrandt; S Hjorth
Journal:  J Neural Transm Gen Sect       Date:  1992
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