Literature DB >> 6208451

The antagonism of bombesin in the CNS by substance P analogues.

A T Yachnis, J N Crawley, R T Jensen, M M McGrane, T W Moody.   

Abstract

The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6208451     DOI： 10.1016/0024-3205(84)90477-6

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  13 in total

1.  In vivo motor effects of substance P on the rat urinary bladder.

Authors:  A Berggren; H Ahlman; A Dahlström; A Rubenson; U Sillén
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575

2.  The lipid-associated 3D structure of SPA, a broad-spectrum neuropeptide antagonist with anticancer properties.

Authors:  David A Keire; Mohanraja Kumar; Weidong Hu; James Sinnett-Smith; Enrique Rozengurt
Journal:  Biophys J       Date:  2006-09-22       Impact factor: 4.033

3.  Pharmacological properties of a C-fibre response evoked by saphenous nerve stimulation in an isolated spinal cord-nerve preparation of the newborn rat.

Authors:  J C Nussbaumer; M Yanagisawa; M Otsuka
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

4.  Effect of vasoactive intestinal peptide, bombesin and substance P on fluid secretion by isolated rat pancreatic ducts.

Authors:  N Ashton; B E Argent; R Green
Journal:  J Physiol       Date:  1990-08       Impact factor: 5.182

5.  Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.

Authors:  M Balestrino; G G Somjen
Journal:  J Physiol       Date:  1988-02       Impact factor: 5.182

6.  Novel selective agonists and antagonists confirm neurokinin NK1 receptors in guinea-pig vas deferens.

Authors:  J M Hall; I K Morton
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

7.  Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat.

Authors:  J Z Guo; K Yoshioka; M Yanagisawa; R Hosoki; R M Hagan; M Otsuka
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

8.  CP-96,345, a non-peptide antagonist of substance P: II. Actions on substance P-induced hypotension and bronchoconstriction, and on depressor reflexes in mammals.

Authors:  T Griesbacher; J Donnerer; F J Legat; F Lembeck
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-09       Impact factor: 3.000

9.  Naloxone-reversible effect of spantide on the spinally mediated behavioural response induced by neurokinin-2 and -3 receptor agonists.

Authors:  T Sakurada; Y Manome; K Katsumata; H Uchiumi; K Tan-No; S Sakurada; K Kisara
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-07       Impact factor: 3.000

10.  Effect of the tachykinin antagonist, [D-Pro4, D-Trp7,9,10] substance P-(4-11), on tachykinin- and histamine-induced inositol phosphate generation in intestinal smooth muscle.

Authors:  S J Bailey; I T Lippe; P Holzer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-03       Impact factor: 3.000
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.