| Literature DB >> 6208375 |
J K Collins, A C Butcher, C A Riegel, V McGrane, C D Blair, Y A Teramoto, S Winston.
Abstract
Monoclonal antibodies were used to study neutralizing determinants on polypeptides of bovine herpesvirus 1. Two of three monoclonal antibodies which recognized nonoverlapping epitopes on a glycoprotein of 82,000 daltons were found to neutralize. A second group of monoclonal antibodies that individually precipitated five viral glycopolypeptides ranging in size from 102,000 to 55,000 daltons also neutralized. Two monoclonal antibodies which were the most efficient in neutralization recognized a non-glycosylated protein of 115,000 daltons which was the major polypeptide on the virus. A fourth group of monoclonal antibodies precipitated a non-glycosylated polypeptide of 91,000 daltons and several smaller polypeptides, but these antibodies demonstrated only limited neutralizing activity.Entities:
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Year: 1984 PMID： 6208375 PMCID： PMC254540
Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103