Literature DB >> 6208374

Aucubin: potential antidote for alpha-amanitin poisoning.

L M Chang, H S Yun, Y S Kim, J W Ahn.   

Abstract

Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.

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Year:  1984        PMID： 6208374     DOI： 10.3109/00099308409035083

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN： 0731-3810


  7 in total

1.  Pharmacokinetic study of an iridoid glucoside: aucubin.

Authors:  N J Suh; C K Shim; M H Lee; S K Kim; I M Chang
Journal:  Pharm Res       Date:  1991-08       Impact factor: 4.200

2.  Beneficial effects of Aucubin on restoration of rabbits with cartilage defect.

Authors:  Gaofeng Zhao; Haiyue Jiang
Journal:  Cell Tissue Bank       Date:  2022-04-06       Impact factor: 1.522

3.  Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus.

Authors:  In-Chi Young; Sung-Ting Chuang; Chia-Hsien Hsu; Yu-Jun Sun; Hwa-Chang Liu; Yo-Shen Chen; Feng-Huei Lin
Journal:  BMC Complement Altern Med       Date:  2017-02-02       Impact factor: 3.659

4.  Aucubin inhibited lipid accumulation and oxidative stress via Nrf2/HO-1 and AMPK signalling pathways.

Authors:  Bingyu Shen; Chenxu Zhao; Yue Wang; Yi Peng; Jiaqi Cheng; Zheng Li; Lin Wu; Meiyu Jin; Haihua Feng
Journal:  J Cell Mol Med       Date:  2019-04-04       Impact factor: 5.310

5.  Aucubin Protects Chondrocytes Against IL-1β-Induced Apoptosis In Vitro And Inhibits Osteoarthritis In Mice Model.

Authors:  Bo-Wei Wang; Yi Jiang; Zi-Long Yao; Bin Yu; Pei-Sheng Chen; Sheng-Nan Wang
Journal:  Drug Des Devel Ther       Date:  2019-10-09       Impact factor: 4.162

Review 6.  The traditional uses, chemical constituents and biological activities of Plantago major L. A review.

Authors:  A B Samuelsen
Journal:  J Ethnopharmacol       Date:  2000-07       Impact factor: 4.360

7.  Aucubin suppresses Titanium particles‑mediated apoptosis of MC3T3‑E1 cells and facilitates osteogenesis by affecting the BMP2/Smads/RunX2 signaling pathway.

Authors:  Ziguan Zhu; Qingping Xie; Yazeng Huang; Shuijun Zhang; Yu Chen
Journal:  Mol Med Rep       Date:  2018-07-16       Impact factor: 2.952
  7 in total

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