Literature DB >> 6208052

Stimulation of histamine synthesis in rat mast cells by compound 48/80 in vitro.

A M Rothschild, I C Fortunato.   

Abstract

The histamine content of rat peritoneal fluid cells is doubled within 20 min by 0.5 microgram/ml of compound 48/80. Histamine catabolism inhibitors do not reproduce this effect; cells pre-incubated with alpha-fluoromethylhistidine are unresponsive to compound 48/80 which therefore activates pre-formed histidine decarboxylase rather than 'inducing' it. Non-mast cells showed no change after treatment with compound 48/80.

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Year:  1984        PMID: 6208052     DOI: 10.1007/bf01971468

Source DB:  PubMed          Journal:  Experientia        ISSN: 0014-4754


  12 in total

1.  A method for the fluorometric assay of histamine in tissues.

Authors:  P A SHORE; A BURKHALTER; V H COHN
Journal:  J Pharmacol Exp Ther       Date:  1959-11       Impact factor: 4.030

2.  Characterization of histidine decarboxylase from rat peritoneal fluid mast cells.

Authors:  A M ROTHSCHILD; R W SCHAYER
Journal:  Biochim Biophys Acta       Date:  1959-08

3.  Adrenaline-stimulated, aspirin-sensitive synthesis of histamine in the rat.

Authors:  A M Rothschild; M P Oliveira Antonio
Journal:  Agents Actions       Date:  1977-07

4.  Histamine release from rat mast cells induced by a mast cell degranulating fraction in bee venom.

Authors:  B Fredholm; O Haegermark
Journal:  Acta Physiol Scand       Date:  1967-04

5.  Stimulation of histamine-forming capacity by antigen in sensitized human leucocytes.

Authors:  E S Assem; H O Schild; M R Vickers
Journal:  Int Arch Allergy Appl Immunol       Date:  1972

6.  Amine formation by rat mast cells in vitro.

Authors:  S A Slorach; B Uvnäs
Journal:  Acta Physiol Scand       Date:  1968-08

7.  Hydrolysis of arginine and tyrosine esters in mast cells exposed to epinephrine.

Authors:  A M Rothschild
Journal:  Biochem Pharmacol       Date:  1980-02       Impact factor: 5.858

8.  Plasma kallikrein-generating activity evoked by rat peritoneal-fluid mast cells following treatment with epinephrine, 8-bromo-cyclic 3',5'-guanosine monophosphate or compound 48/80.

Authors:  A M Rothschild
Journal:  Biochem Pharmacol       Date:  1981-03-01       Impact factor: 5.858

9.  Selective inhibitors of biosynthesis of aminergic neurotransmitters.

Authors:  J Kollonitsch; L M Perkins; A A Patchett; G A Doldouras; S Marburg; D E Duggan; A L Maycock; S D Aster
Journal:  Nature       Date:  1978-08-31       Impact factor: 49.962

10.  Effect of sympathomimetic amines on the histamine forming capacity of human leucocytes.

Authors:  E S Assem
Journal:  Br J Pharmacol       Date:  1974-10       Impact factor: 8.739

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