Literature DB >> 6207999

Isolation and DNA sequence of full-length cDNA and of the entire gene for human apolipoprotein AI--discovery of a new genetic polymorphism in the apo AI gene.

J J Seilhamer, A A Protter, P Frossard, B Levy-Wilson.   

Abstract

We have isolated full-length cDNA clones for apolipoprotein AI from a human fetal liver cDNA library made in the vector lambda gt10. One such clone, pBL13AI, was 965 nucleotides long and contained the entire preproapolipoprotein AI sequence, in addition to 86 nucleotides of 5' untranslated region and 75 nucleotides of the 3' untranslated region. The complete structure of this clone is presented. Furthermore, we have obtained a 20-kb genomic fragment from a human genomic library, encompassing the entire apo AI gene. Sequence analysis of the gene shows that the coding region is interrupted by three introns of 197, 187, and 588 bp, respectively. Digestion of the DNA of various individuals with the endonuclease Msp I revealed a new restriction site polymorphism in the apo AI gene.

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Year:  1984        PMID： 6207999     DOI： 10.1089/dna.1.1984.3.309

Source DB:  PubMed          Journal:  DNA        ISSN： 0198-0238


  17 in total

1.  Haplotypes identified by DNA polymorphisms at the apolipoprotein A-1 and C-III loci and hypertriglyceridaemia. A study in a Japanese population.

Authors:  A Rees; J Stocks; H Paul; Y Ohuchi; D Galton
Journal:  Hum Genet       Date:  1986-02       Impact factor: 4.132

2.  Isolation of a cDNA clone encoding the amino-terminal region of human apolipoprotein B.

Authors:  A A Protter; D A Hardman; J W Schilling; J Miller; V Appleby; G C Chen; S W Kirsher; G McEnroe; J P Kane
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

3.  DNA polymorphism haplotypes of the human apolipoprotein APOA1-APOC3-APOA4 gene cluster.

Authors:  S E Antonarakis; P Oettgen; A Chakravarti; S L Halloran; R R Hudson; L Feisee; S K Karathanasis
Journal:  Hum Genet       Date:  1988-11       Impact factor: 4.132

4.  The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes.

Authors:  E A Thompson; S Deeb; D Walker; A G Motulsky
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

5.  Haplotypes identified by DNA restriction-fragment-length polymorphisms in the A-1 C-III A-IV gene region and hypertriglyceridemia.

Authors:  J Stocks; H Paul; D Galton
Journal:  Am J Hum Genet       Date:  1987-08       Impact factor: 11.025

6.  DNA polymorphic patterns and haplotype arrangements of the apo A-1, apo C-III, apo A-IV gene cluster in different ethnic groups.

Authors:  H Paul; D Galton; J Stocks
Journal:  Hum Genet       Date:  1987-03       Impact factor: 4.132

7.  An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population.

Authors:  Q Zeng; M Dammerman; Y Takada; A Matsunaga; J L Breslow; J Sasaki
Journal:  Hum Genet       Date:  1995-04       Impact factor: 4.132

8.  High density lipoprotein deficiency with xanthomas. A defect in reverse cholesterol transport caused by a point mutation in the apolipoprotein A-I gene.

Authors:  K J Lackner; H Dieplinger; G Nowicka; G Schmitz
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

9.  BanI dimorphic site in the third intron of the human apolipoprotein AI gene (Apo A1).

Authors:  P M Frossard; R T Coleman; D W Lim
Journal:  Nucleic Acids Res       Date:  1987-01-12       Impact factor: 16.971

10.  Deletion of the propeptide of apolipoprotein A-I impairs exit of nascent apolipoprotein A-I from the endoplasmic reticulum.

Authors:  R S McLeod; C Robbins; A Burns; Z Yao; P H Pritchard
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857
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