Literature DB >> 6207877

Colocalization of U1 and U2 small nuclear RNPs by immunocytochemistry.

D L Spector.   

Abstract

The in situ localization of U1 and U2 snRNPs was examined, using autoantibodies directed against each of these snRNPs, by immunofluorescence and immunoelectron microscopy. This study has shown U1 and U2 snRNPs to colocalize in the nuclei of PtK2 cells. Thirty to fifty immunostained clusters were observed per interphase nucleus. This study suggests these nuclear protein clusters to be the sites of RNA processing.

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Year:  1984        PMID： 6207877     DOI： 10.1111/j.1768-322x.1984.tb00289.x

Source DB:  PubMed          Journal:  Biol Cell        ISSN： 0248-4900            Impact factor:   4.458


  19 in total

1.  Differences in snRNP localization between transformed and nontransformed cells.

Authors:  D L Spector; G Lark; S Huang
Journal:  Mol Biol Cell       Date:  1992-05       Impact factor: 4.138

2.  U1 and U2 small nuclear RNAs are present in nuclear speckles.

Authors:  S Huang; D L Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

3.  Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

Authors:  D L Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

4.  Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus.

Authors:  J A Potashkin; R J Derby; D L Spector
Journal:  Mol Cell Biol       Date:  1990-07       Impact factor: 4.272

Review 5.  Localisation of splicing snRNPs in mammalian cells.

Authors:  A I Lamond; M Carmo-Fonseca
Journal:  Mol Biol Rep       Date:  1993-08       Impact factor: 2.316

6.  Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries.

Authors:  R M Zirbel; U R Mathieu; A Kurz; T Cremer; P Lichter
Journal:  Chromosome Res       Date:  1993-07       Impact factor: 5.239

7.  Intranuclear appearance of the phosphorylated form of cytoskeleton-associated 350-kDa proteins in U1-ribonucleoprotein regions after growth stimulation of fibroblasts.

Authors:  C Sato; K Nishizawa; T Nakayama; K Nose; Y Takasaki; S Hirose; H Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

8.  The herpes simplex virus type 1 regulatory protein ICP27 coimmunoprecipitates with anti-Sm antiserum, and the C terminus appears to be required for this interaction.

Authors:  R M Sandri-Goldin; M K Hibbard
Journal:  J Virol       Date:  1996-01       Impact factor: 5.103

9.  The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing.

Authors:  R M Sandri-Goldin; M K Hibbard; M A Hardwicke
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

10.  Mammalian nuclei contain foci which are highly enriched in components of the pre-mRNA splicing machinery.

Authors:  M Carmo-Fonseca; D Tollervey; R Pepperkok; S M Barabino; A Merdes; C Brunner; P D Zamore; M R Green; E Hurt; A I Lamond
Journal:  EMBO J       Date:  1991-01       Impact factor: 11.598
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