Literature DB >> 620724

Mitogenicity of autolysates of Trypanosoma congolense.

R K Assoku, I R Tizard.   

Abstract

Autolysates of Trypanosoma congolense, in subcytotoxic amounts, were found to be highly mitogenic in vitro for the spleen cells of normal mice. Significant amounts of [3H]-thymidine were also incorporated by the responding spleen cells of nu/nu (athymic) mice. In contrast, the spleen cells of cyclophosphamide-treated mice were unresponsive. The findings suggest that a potent B-cell-mitogen is generated by the autolysing T. congolense organism.

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Year:  1978        PMID： 620724     DOI： 10.1007/bf01921943

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  Immunodepression, high IgM levels and evasion of the immune response in murine trypanosomiasis.

Authors:  K M Hudson; C Byner; J Freeman; R J Terry
Journal:  Nature       Date:  1976-11-18       Impact factor: 49.962

2.  Suppressor cells in experimentally trypanosomiasis.

Authors:  A N Jayawardena; B H Waksman
Journal:  Nature       Date:  1977-02-10       Impact factor: 49.962

3.  The nature of immunosuppression in Trypanosoma brucei infections in mice. II. The role of the T and B lymphocytes.

Authors:  P K Murray; F W Jennings; M Murray; G M Urquhart
Journal:  Immunology       Date:  1974-11       Impact factor: 7.397

4.  Fluorescence-activated cell sorting of human T and B lymphocytes. II. Identification of the cell type responsible for interferon production and cell proliferation in response to mitogens.

Authors:  L B Epstein; H W Kreth; L A Herzenberg
Journal:  Cell Immunol       Date:  1974-06       Impact factor: 4.868

5.  Immunosuppression in bovine trypanosomiasis.

Authors:  P H Holmes; E Mammo; A Thomson; P A Knight; R Lucken; P K Murray; M Murray; F W Jennings; G M Urquhart
Journal:  Vet Rec       Date:  1974-07-27       Impact factor: 2.695

6.  Immunosuppression in Trypanosoma brucei infections in rats and mice.

Authors:  G M Urquhart; M Murray; P K Murray; F W Jennings; E Bate
Journal:  Trans R Soc Trop Med Hyg       Date:  1973       Impact factor: 2.184

7.  Immunosuppression during trypanosomiasis.

Authors:  L G Goodwin; D G Green; M W Guy; A Voller
Journal:  Br J Exp Pathol       Date:  1972-02

8.  Free fatty acids and pathogenesis of African trypanosomiasis.

Authors:  I R Tizard; K Nielsen; A Mellors; R K Assoku
Journal:  Lancet       Date:  1977-04-02       Impact factor: 79.321

9.  Immunosuppressive activity of Phaseolus coccineus and Phaseolus vulgaris extracts in mice.

Authors:  R A Calderón; F Córdoba
Journal:  Eur J Immunol       Date:  1976-07       Impact factor: 5.532

10.  Cellular recognition by mouse lymphocytes in vitro. I. Definition of a new technique and results of stimulation by phytohemagglutinin and specific antigens.

Authors:  W H Adler; T Takiguchi; B Marsh; R T Smith
Journal:  J Exp Med       Date:  1970-06-01       Impact factor: 14.307
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  9 in total

1.  Immunomodulation by Histoplasma capsulatum products; polyclonal activation and mitogenic effects.

Authors:  B H Ruiz; R E Carvajal
Journal:  Mycopathologia       Date:  1986-02       Impact factor: 2.574

Review 2.  Biologically active products from African Trypanosomes.

Authors:  I Tizard; K H Nielsen; J R Seed; J E Hall
Journal:  Microbiol Rev       Date:  1978-12

3.  Evidence for depletion of Ia+ macrophages and associated immunosuppression in African trypanosomiasis.

Authors:  O Bagasra; R F Schell; J L Le Frock
Journal:  Infect Immun       Date:  1981-04       Impact factor: 3.441

4.  Humoral suppression in Trypanosoma cruzi infection in relation to the timing of antigen presentation.

Authors:  A C Corsini; O L Oliveira; M G Costa
Journal:  Z Parasitenkd       Date:  1980

5.  The immunosuppressive and mitogenic effects of Trypanosoma musculi.

Authors:  C A Hazlett; I R Tizard
Journal:  Clin Exp Immunol       Date:  1978-08       Impact factor: 4.330

6.  High and low responsiveness of bovine lymphocytes to Trypanosoma brucei in vitro: lack of correlation with resistance to trypanosomiasis.

Authors:  F Fumoux; T Traore-Leroux; R Queval; M Pinder; G E Roelants
Journal:  Immunology       Date:  1985-01       Impact factor: 7.397

7.  The in vitro response to mitogens of leucocytes from cattle infected with Trypanosoma congolense.

Authors:  R A Masake; T W Pearson; P Wells; G E Roelants
Journal:  Clin Exp Immunol       Date:  1981-03       Impact factor: 4.330

8.  Murine trypanosomiasis: cellular proliferation and functional depletion in the blood, peritoneum, and spleen related to changes in bone marrow stem cells.

Authors:  C E Clayton; M E Selkirk; C A Corsini; B M Ogilvie; B A Askonas
Journal:  Infect Immun       Date:  1980-06       Impact factor: 3.441

9.  Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. II. Immunobiological dysfunctions.

Authors:  Marie Christine Blom-Potar; Nathalie Chamond; Alain Cosson; Grégory Jouvion; Sabrina Droin-Bergère; Michel Huerre; Paola Minoprio
Journal:  PLoS Negl Trop Dis       Date:  2010-08-10
  9 in total

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