Literature DB >> 620717

Activation of the carcinogen N-hydroxy-2-acetylaminofluorene by rat mammary peroxidase.

D L Reigh, M Stuart, R A Floyd.   

Abstract

A peroxidase preparation from rat mammary gland parenchymal cells, a target tissue of arylamine carcinogens, was shown to activate the carcinogen N-hydroxy-2-acetylaminofluorene via a nitroxyl free radical intermediate to the more active carcinogens nitrosofluorene and N-acetoxy-2-acetylaminofluorene. Hydrogen peroxide, cumene hydroperoxide, and linoleic acid hydroperoxide were effective as substrates. The antioxidants ascorbate, propyl gallate and reduced glutathione prevented the free radical activation route.

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Year:  1978        PMID： 620717     DOI： 10.1007/bf01921931

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Techniques for studying development of normal mammary epithelial cells in organ culture.

Authors:  R J Topper; T Oka; B K Vonderhaar
Journal:  Methods Enzymol       Date:  1975       Impact factor: 1.600

2.  The N- and ring-hydroxylation of 2-acetylaminofluorene and the failure to detect N-acetylation of 2-aminofluorene in the dog.

Authors:  L A POIRIER; J A MILLER; E C MILLER
Journal:  Cancer Res       Date:  1963-06       Impact factor: 12.701

3.  Obligatory free radical intermediate in the oxidative activation of the carcinogen N-hydroxy-2-acetylaminofluorene.

Authors:  R A Floyd; L M Soong
Journal:  Biochim Biophys Acta       Date:  1977-06-23

4.  Mammary carcinogenesis in the rat by topical application of fluorenylhydroxamic acids.

Authors:  D Malejka-Giganti; H R Gutmann; R E Rydell
Journal:  Cancer Res       Date:  1973-10       Impact factor: 12.701

5.  Horseradish peroxidase/hydrogen peroxide-catalyzed oxidation of the carcinogen N-hydroxy-N-acetyl-2-aminofluorene as effected by cyanide and ascorbate.

Authors:  R A Floyd; L M Soong; P L Culver
Journal:  Cancer Res       Date:  1976-04       Impact factor: 12.701

6.  Lipid hydroperoxide activation of N-hydroxy-N-acetylaminofluorene via a free radical route.

Authors:  R A Floyd; L M Soong; R N Walker; M Stuart
Journal:  Cancer Res       Date:  1976-08       Impact factor: 12.701

7.  On the metabolic activation of N-hydroxy-N-2-acetylamino-fluorene. II. Simultaneous formation of 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene from N-hydroxy-N-2-acetylaminofluorene via a free radical intermediate.

Authors:  H Bartsch; M Traut; E Hecker
Journal:  Biochim Biophys Acta       Date:  1971-06-22

8.  On the metabolic activation of the carcinogen N-hydroxy-N-2-acetylaminofluorene. 3. Oxidation with horseradish peroxidase to yield 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene.

Authors:  H Bartsch; E Hecker
Journal:  Biochim Biophys Acta       Date:  1971-06-22

9.  N-acetoxy-N-acetylaminoarenes and nitrosoarenes. One-electron non-enzymatic and enzymatic oxidation products of various carcinogenic aromatic acethydroxamic acids.

Authors:  H Bartsch; J A Miller; E C Miller
Journal:  Biochim Biophys Acta       Date:  1972-06-26
  9 in total
  1 in total

1.  Role of radical cations in aromatic hydrocarbon carcinogenesis.

Authors:  E Cavalieri; E Rogan
Journal:  Environ Health Perspect       Date:  1985-12       Impact factor: 9.031
  1 in total

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