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Literature DB >> 6207110

Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies.

Abstract

A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially "rheumatogenic" serotypes.

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Year: 1984 PMID： 6207110 PMCID： PMC261470 DOI： 10.1128/iai.46.1.267-269.1984

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

16 in total

1. Primary structure of streptococcal Pep M5 protein: Absence of extensive sequence repeats.

Authors: B N Manjula; S M Mische; V A Fischetti
Journal: Proc Natl Acad Sci U S A Date: 1983-09 Impact factor: 11.205

2. Primary structure of protective antigens of type 24 streptococcal M protein.

Authors: E H Beachey; J M Seyer; A H Kang
Journal: J Biol Chem Date: 1980-07-10 Impact factor: 5.157

3. Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein.

Authors: E H Beachey; J M Seyer; J B Dale; W A Simpson; A H Kang
Journal: Nature Date: 1981-07-30 Impact factor: 49.962

4. Epitope-specific protective immunogenicity of chemically synthesized 13-, 18-, and 23-residue peptide fragments of streptococcal M protein.

Authors: E H Beachey; A Tartar; J M Seyer; L Chedid
Journal: Proc Natl Acad Sci U S A Date: 1984-04 Impact factor: 11.205

5. Repeating covalent structure and protective immunogenicity of native and synthetic polypeptide fragments of type 24 streptococcal M protein. Mapping of protective and nonprotective epitopes with monoclonal antibodies.

Authors: E H Beachey; J M Seyer; J B Dale; D L Hasty
Journal: J Biol Chem Date: 1983-11-10 Impact factor: 5.157

6. Hybridoma antibodies against protective and nonprotective antigenic determinants of a structurally defined polypeptide fragment of streptococcal M protein.

Authors: D L Hasty; E H Beachey; W A Simpson; J B Dale
Journal: J Exp Med Date: 1982-04-01 Impact factor: 14.307

7. Protective antigenic determinant of streptococcal M protein shared with sarcolemmal membrane protein of human heart.

Authors: J B Dale; E H Beachey
Journal: J Exp Med Date: 1982-10-01 Impact factor: 14.307

8. ANTIGENIC PROPERTIES OF THE TYPE-SPECIFIC SUBSTANCE DERIVED FROM GROUP A HEMOLYTIC STREPTOCOCCI.

Authors: G K Hirst; R C Lancefield
Journal: J Exp Med Date: 1939-02-28 Impact factor: 14.307

9. Streptococcal M protein extracted by nonionic detergent. III. Correlation between immunological cross-reactions and structural similarities with implications for antiphagocytosis.

Authors: V A Fischetti
Journal: J Exp Med Date: 1978-06-01 Impact factor: 14.307

10. Purification and properties of M protein extracted from group A streptococci with pepsin: covalent structure of the amino terminal region of type 24 M antigen.

Authors: E H Beachey; G H Stollerman; E Y Chiang; T M Chiang; J M Seyer; A H Kang
Journal: J Exp Med Date: 1977-06-01 Impact factor: 14.307

13 in total

1. New protective antigen of group A streptococci.

Authors: J B Dale; E Y Chiang; S Liu; H S Courtney; D L Hasty
Journal: J Clin Invest Date: 1999-05 Impact factor: 14.808

2. Expression of protective and cardiac tissue cross-reactive epitopes of type 5 streptococcal M protein in Escherichia coli.

Authors: T P Poirier; M A Kehoe; J B Dale; K N Timmis; E H Beachey
Journal: Infect Immun Date: 1985-04 Impact factor: 3.441

Review 3. Molecular aspects of the phagocytosis resistance of group A streptococci.

Authors: B N Manjula
Journal: Eur J Epidemiol Date: 1988-09 Impact factor: 8.082

4. Conservation of protective and nonprotective epitopes in M proteins of group A streptococci.

Authors: L Miller; V Burdett; T P Poirier; L D Gray; E H Beachey; M A Kehoe
Journal: Infect Immun Date: 1988-08 Impact factor: 3.441

Review 5. Streptococcal M protein: molecular design and biological behavior.

Authors: V A Fischetti
Journal: Clin Microbiol Rev Date: 1989-07 Impact factor: 26.132

6. Molecular evolution of streptococcal M protein: cloning and nucleotide sequence of the type 24 M protein gene and relation to other genes of Streptococcus pyogenes.

Authors: A R Mouw; E H Beachey; V Burdett
Journal: J Bacteriol Date: 1988-02 Impact factor: 3.490